ArticleFrontiers in cardiovascular medicine2023
Thoracic aortopathy in Marfan syndrome overlaps with mechanisms seen in bicuspid aortic valve disease.
Article in Frontiers in cardiovascular medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Co-creating a patient-driven digital monitoring agenda for thoracic aortic disease: a multiphase qualitative study.BMJ open · 2026Article
- TRPV4 is Associated with a Marfan Syndrome-Related Mechanosensitive Gene Program in Aortic Smooth Muscle Cells.Biochemical genetics · 2026Article
- Establishing reference values for aortic dimensions in the general Indian population and implications for global standards.Indian journal of thoracic and cardiovascular surgery · 2026Article
- Exploring Disparities in Atherosclerosis Comorbidity with Aortic Aneurysm.Biomedicines · 2025Review
- Aortic root replacement for bicuspid aortic valve dysfunction does not impair survival rates.Journal of cardiothoracic surgery · 2024Article
- Practical Considerations of Remote Care in Thoracic Aortopathy in India.Journal of clinical medicine · 2024Article
- Treatment strategies and outcomes following acute type A aortic dissection repair in patients with bicuspid and tricuspid aortic valves: A meta-analysis.JTCVS open · 2024Article
- Smooth muscle cell phenotypic switching occurs independent of aortic dilation in bicuspid aortic valve-associated ascending aortas.PloS one · 2024Article
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Authors and funding
6 authors.
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Abstract
Background: Thoracic aortopathy is a serious complication which is more often seen in patients with Marfan syndrome (MFS) and patients with a bicuspid aortic valve (BAV) than in individuals with a tricuspid aortic valve (TAV). The identification of common pathological mechanisms leading to aortic complications in non-syndromic and syndromic diseases would significantly improve the field of personalized medicine. Objective: This study sought to compare thoracic aortopathy between MFS, BAV, and TAV individuals. Materials and methods: Bicuspid aortic valve (BAV; Results: The MFS group showed many similarities with the dilated BAV. Both patient groups showed a thinner intima ( Conclusion: This study showed important similarities in the pathogenesis of thoracic aortic aneurysms in BAV and MFS. These common mechanisms can be further investigated to personalize treatment strategies in non-syndromic and syndromic conditions.
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