Evidence map›Paper›PMID 36844541›Full record

ArticleACS omega2023

Parasites, Infections, and Inoculation in Synthetic Minimal Cells.

Brock Cash, Nathaniel J Gaut, Christopher Deich, Laura L Johnson, Aaron E Engelhart, Katarzyna P Adamala

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ACS omega, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Brock CashDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Nathaniel J GautDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Christopher DeichDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Laura L JohnsonDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Aaron E EngelhartDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.
Katarzyna P AdamalaDepartment of Genetics, Cell Biology and Development, University of Minnesota, Minneapolis, Minnesota 55455, United States.ORCID https://orcid.org/0000-0003-1066-7207

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Synthetic minimal cells provide a controllable and engineerable model for biological processes. While much simpler than any live natural cell, synthetic cells offer a chassis for investigating the chemical foundations of key biological processes. Herein, we show a synthetic cell system with host cells, interacting with parasites and undergoing infections of varying severity. We demonstrate how the host can be engineered to resist infection, we investigate the metabolic cost of carrying resistance, and we show an inoculation that immunizes the host against pathogens. Our work expands the synthetic cell engineering toolbox by demonstrating host-pathogen interactions and mechanisms for acquiring immunity. This brings synthetic cell systems one step closer to providing a comprehensive model of complex, natural life.

Identifiers

PMID36844541
PMCPMC9948217

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.