Evidence map›Paper›PMID 36844456›Full record

ArticleiScience2023

New insights from GWAS on BMI-related growth traits in a longitudinal cohort of admixed children with Native American and European ancestry.

Lucas Vicuña, Esteban Barrientos, Tomás Norambuena, Danilo Alvares, Juan Cristobal Gana, Valeria Leiva-Yamaguchi, Cristian Meza, José L Santos, Veronica Mericq, Ana Pereira and 1 more

Abstract read
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Lucas VicuñaFaculty of Engineering and Sciences, Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.
Esteban BarrientosFaculty of Engineering and Sciences, Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.
Tomás NorambuenaFaculty of Engineering and Sciences, Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.
Danilo AlvaresMRC Biostatistics Unit, University of Cambridge, Cambridge, UK.
Juan Cristobal GanaDepartment of Pediatric Gastroenterology and Nutrition, Division of Pediatrics, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Valeria Leiva-YamaguchiDepartment of Statistics, Pontificia Universidad Católica de Chile, Santiago, Chile.
Cristian MezaINGEMAT-CIMFAV, Faculty of Engineering, Universidad de Valparaiso, Valparaiso, Chile.
José L SantosDepartment of Nutrition, Diabetes and Metabolism, School of Medicine, Pontificia Universidad Católica de Chile, Santiago, Chile.
Veronica MericqInstitute of Maternal and Child Research, Faculty of Medicine, University of Chile, Santiago, Chile.
Ana PereiraInstitute of Nutrition and Food Technology, University of Chile, Santiago, Chile.
Susana EyheramendyFaculty of Engineering and Sciences, Universidad Adolfo Ibáñez, Peñalolén, Santiago, Chile.

Funding

Medical Research Council MC_UU_00002/5
6 · The paper itself

Abstract

Body-mass index (BMI) is a hallmark of adiposity. In contrast with adulthood, the genetic architecture of BMI during childhood is poorly understood. The few genome-wide association studies (GWAS) on children have been performed almost exclusively in Europeans and at single ages. We performed cross-sectional and longitudinal GWAS for BMI-related traits on 904 admixed children with mostly Mapuche Native American and European ancestries. We found regulatory variants of the immune gene

Indexed as

GenomicsHealth sciencesHuman genetics

Identifiers

PMID36844456
PMCPMC9947275

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.