Evidence map›Paper›PMID 36844418›Full record

ArticleBehavioural neurology2023

Naringin Protects against Tau Hyperphosphorylation in A

Qi Qiu, Xia Lei, Yueying Wang, Hui Xiong, Yanming Xu, Huifeng Sun, Hongdan Xu, Ning Zhang

Abstract read
In one paragraph

Article in Behavioural neurology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. The role of PI3K signaling pathway in Alzheimer's disease.Frontiers in aging neuroscience · 2024
    Review
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Qi QiuCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
Xia LeiCollege of Jiamusi, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154007, China.
Yueying WangCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
Hui XiongCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
Yanming XuCollege of Jiamusi, Heilongjiang University of Chinese Medicine, Jiamusi, Heilongjiang 154007, China.
Huifeng SunCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.
Hongdan XuDepartment of Pharmacy, Higher Health Vocational Technology School, Wuxi 214000, China.ORCID https://orcid.org/0000-0002-7920-0069
Ning ZhangCollege of Pharmacy, Heilongjiang University of Chinese Medicine, Harbin, Heilongjiang 150040, China.ORCID https://orcid.org/0000-0003-0399-5085

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is the most common form of dementia and a significant social and economic burden. Estrogens can exert neuroprotective effects and may contribute to the prevention, attenuation, or even delay in the onset of AD; however, long-term estrogen therapy is associated with harmful side effects. Thus, estrogen alternatives are of interest for countering AD. Naringin, a phytoestrogen, is a key active ingredient in the traditional Chinese medicine Drynaria. Naringin is known to protect against nerve injury induced by amyloid beta-protein (A

Indexed as

Alzheimer DiseaseNeuroprotective AgentsAmyloid beta-PeptidesAnimalsEstrogensFlavanonesGlycogen Synthase Kinase 3 betaMiceMice, Inbred C57BLPC12 CellsPhosphatidylinositol 3-KinasesPhosphorylationProto-Oncogene Proteins c-aktRatsReceptors, EstrogenSignal TransductionAmyloid beta-PeptidesEstrogensFlavanonesGlycogen Synthase Kinase 3 betanaringinNeuroprotective AgentsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktReceptors, Estrogentau Proteins

Identifiers

PMID36844418
PMCPMC9946756

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.