Evidence map›Paper›PMID 36844374›Full record

ReviewCritical care explorations2023

Insulin Infusion Dosing in Pediatric Diabetic Ketoacidosis: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.

Ben Forestell, Frank Battaglia, Sameer Sharif, Mohamed Eltorki, M Constantine Samaan, Karen Choong, Bram Rochwerg

Registry-linked trialAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Critical care explorations, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07377604 (Impact of Anemia on Time to Resolution of Diabetic Ketoacidosis and Hospital Outcomes in Children), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07377604 active not recruitingnot on this map

Impact of Anemia on Time to Resolution of Diabetic Ketoacidosis and Hospital Outcomes in Children: A Single-Center Retrospective Cohort Study

TypeobservationalSponsorAydin Adnan Menderes UniversityRan2013 to 2026Enrolled150ConditionsDiabete Type 1, Ketoacidosis, Diabetic, Pediatrics, Child
3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Trial
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Ben ForestellDepartment of Medicine, Division of Emergency Medicine, McMaster University, Hamilton, ON, Canada.
Frank BattagliaDepartment of Medicine, Division of Emergency Medicine, McMaster University, Hamilton, ON, Canada.
Sameer SharifDepartment of Medicine, Division of Emergency Medicine, McMaster University, Hamilton, ON, Canada.
Mohamed EltorkiDepartment of Pediatrics, Division of Pediatric Emergency Medicine, McMaster University, Hamilton, ON, Canada.
M Constantine SamaanDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Karen ChoongDepartment of Health Research Methods, Evidence and Impact, McMaster University, Hamilton, ON, Canada.
Bram RochwergDepartment of Medicine, Division of Critical Care, McMaster University, Hamilton, ON, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

In children with diabetic ketoacidosis (DKA), insulin infusions are the mainstay of treatment; however, optimal dosing remains unclear. Our objective was to compare the efficacy and safety of different insulin infusion doses for the treatment of pediatric DKA. DATA SOURCES: We searched MEDLINE, EMBASE, PubMed, and Cochrane from inception to April 1, 2022. STUDY SELECTION: We included randomized controlled trials (RCTs) of children with DKA comparing intravenous insulin infusion administered at 0.05 units/kg/hr (low dose) versus 0.1 units/kg/hr (standard dose). DATA EXTRACTION: We extracted data independently and in duplicate and pooled using a random effects model. We assessed the overall certainty of evidence for each outcome using the Grading Recommendations Assessment, Development and Evaluation approach. DATA SYNTHESIS: We included four RCTs (

conclusionsIn children with DKA, the use of low-dose insulin infusion is probably as efficacious as standard-dose insulin, and probably reduces treatment-related adverse events. Imprecision limited the certainty in the outcomes of interest, and the generalizability of the results is limited by all studies being performed in a single country.

Indexed as

critical carediabetes mellitusdiabetic ketoacidosisdrug dosinginsulin

Identifiers

PMID36844374
PMCPMC9943979

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.