Evidence map›Paper›PMID 36844373›Full record

ArticleInorganics2020

Exploring Serum Transferrin Regulation of Nonferric Metal Therapeutic Function and Toxicity.

Josué A Benjamín-Rivera, Andrés E Cardona-Rivera, Ángel L Vázquez-Maldonado, Christian Y Dones-Lassalle, Héctor L Pabón-Colon, Héctor M Rodríguez-Rivera, Israel Rodríguez, Jean C González-Espiet, Jessika Pazol, Jobaniel D Pérez-Ríos and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Inorganics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Solution speciation and human serum protein binding of indium(III) complexes of 8-hydroxyquinoline, deferiprone and maltol.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2022
    Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Josué A Benjamín-RiveraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).ORCID 0000-0002-9460-9954
Andrés E Cardona-RiveraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Ángel L Vázquez-MaldonadoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Christian Y Dones-LassalleDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Héctor L Pabón-ColonDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Héctor M Rodríguez-RiveraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Israel RodríguezDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Jean C González-EspietDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Jessika PazolDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).ORCID 0000-0001-5772-696X
Jobaniel D Pérez-RíosDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
José F Catala-TorresDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Marielie Carrasquillo RiveraDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Michael G De Jesus-SotoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Nicolle A Cordero-VirellaDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Paola M Cruz-MaldonadoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Patricia González-PaganDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Raul Hernández-RíosDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Kavita GaurDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).
Sergio A Loza-RosasDepartamento de Química y Bioquímica, Facultad de Ciencias e Ingeniería, Universidad de Boyacá, Tunja 150003, Colombia.
Arthur D TinocoDepartment of Chemistry, University of Puerto Rico, Río Piedras Campus, Río Piedras, PR 00931, USA).ORCID 0000-0003-2825-5235

Funding

SCIENCE AND TECHNOLOGY COMPETENCY & EDUCATION CORE (STCE)P20GM103475 · NIGMS · UNIVERSITY OF PUERTO RICO MED SCIENCES · PI Jose R. Rodriguez-Medina · 2012 to 2026
$52.9M
Upgrade Laboratories Facilities at UPR-Rio PiedrasR25GM061151 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 2001 to 2023
$32.5M
RIO PIEDRAS MARC U*STAR DEVELOPMENT PROGRAMT34GM007821 · NIGMS · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI CARBALLEIRA, NESTOR MANUEL · 1985 to 2020
$20.3M
Development of Peptide-Conjugate Biomimics for Targeted Ti(IV)-Based Anticancer DSC1CA190504 · NCI · UNIVERSITY OF PUERTO RICO RIO PIEDRAS · PI TINOCO, ARTHUR DAVID · 2014 to 2017
$1.4M
NCI NIH HHS SC1 CA190504NIGMS NIH HHS P20 GM103475NIGMS NIH HHS R25 GM061151NIGMS NIH HHS T34 GM007821
6 · The paper itself

Abstract

Serum transferrin (sTf) plays a pivotal role in regulating iron biodistribution and homeostasis within the body. The molecular details of sTf Fe(III) binding blood transport, and cellular delivery through transferrin receptor-mediated endocytosis are generally well-understood. Emerging interest exists in exploring sTf complexation of nonferric metals as it facilitates the therapeutic potential and toxicity of several of them. This review explores recent X-ray structural and physiologically relevant metal speciation studies to understand how sTf partakes in the bioactivity of key non-redox active hard Lewis acidic metals. It challenges preconceived notions of sTf structure function correlations that were based exclusively on the Fe(III) model by revealing distinct coordination modalities that nonferric metal ions can adopt and different modes of binding to metal-free and Fe(III)-bound sTf that can directly influence how they enter into cells and, ultimately, how they may impact human health. This knowledge informs on biomedical strategies to engineer sTf as a delivery vehicle for metal-based diagnostic and therapeutic agents in the cancer field. It is the intention of this work to open new avenues for characterizing the functionality and medical utility of nonferric-bound sTf and to expand the significance of this protein in the context of bioinorganic chemistry.

Indexed as

bioactivitybioavailabilityendocytosismetal therapeutic function and toxicitymetal transportnonferric metal ionsserum transferrin

Identifiers

PMID36844373
PMCPMC9957567

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.