ArticleFrontiers in medicine2023
Low-dose topiramate and hydrochlorothiazide-associated early acute myopia and angle narrowing: A case report.
Article in Frontiers in medicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hydrochlorothiazide and chlorthalidone use and glaucoma risk: pharmacovigilance analysis and nationwide cohort study.Frontiers in pharmacology · 2026Article
- Evaluation of the Accuracy and Reliability of Responses Generated by Artificial Intelligence Related to Clinical Pharmacology.Journal of clinical medicine · 2025Article
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Authors and funding
6 authors.
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Abstract
Purpose: To report a unique case of topiramate and hydrochlorothiazide associated with acute myopia and angle narrowing. Patients and methods: A 34-year-old Asian woman presented with prominent binocular visual acuity decrease 6 h after taking only one dose of 25 mg topiramate, 25 mg hydrochlorothiazide, and 22.4 mg fluoxetine to lose weight. She was subsequently diagnosed with acute bilateral myopia and angle narrowing and was started on topical therapy. Results: Initial examination revealed a decreased visual acuity of 20/100 bilaterally, an elevated intraocular pressure of 23 mmHg in the right eye and 24 mmHg in the left eye, suprachoroidal effusions, and angle narrowing. After the discontinuation of these drugs and the use of IOP-lowering medication, the patient made full recovery. Conclusion: We speculate that there is a drug-drug interaction between topiramate and hydrochlorothiazide that may lead to the angle narrowing in a short time and at a low dose. Timely discontinuation of the drug usually leads to complete recovery within days to weeks.
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