Evidence map›Paper›PMID 36844148›Full record

ArticleBrain communications2023

Brain glucose metabolism and nigrostriatal degeneration in isolated rapid eye movement sleep behaviour disorder.

Patricia Diaz-Galvan, Toji Miyagawa, Scott A Przybelski, Timothy G Lesnick, Matthew L Senjem, Clifford R Jack, Leah K Forsberg, Hoon-Ki Min, Erik K St Louis, Rodolfo Savica and 6 more

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Brain communications, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01453127 (DaTSCAN Imaging in Aging and Neurodegenerative Disease), which is not on this map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.4field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01453127 phase4enrolling by invitationnot on this map

DaTSCAN Imaging in Aging and Neurodegenerative Disease

TypeinterventionalSponsorMayo ClinicRan2011 to 2026Enrolled500ConditionsDementia, Parkinsonism, Mild Cognitive Impairment, REM Sleep Behavior DisorderArmsI-123 Ioflupane solution injection prior to SPECT scan (DaTscan), Single photon emission computed tomography (SPECT) scan
3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 20 citations in OpenAlex.

  1. [Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Implications and opportunities regarding biological frameworks in overt and prodromal dementia with Lewy bodies.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 1 country.

Patricia Diaz-GalvanDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Toji MiyagawaDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Scott A PrzybelskiDepartment of Quantitative Health Science, Mayo Clinic, Rochester, MN 55905, USA.
Timothy G LesnickDepartment of Quantitative Health Science, Mayo Clinic, Rochester, MN 55905, USA.
Matthew L SenjemDepartment of Information Technology, Mayo Clinic, Rochester, MN 55905, USA.
Clifford R JackDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0001-7916-622X
Leah K ForsbergDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Hoon-Ki MinDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Erik K St LouisDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-2833-8826
Rodolfo SavicaDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Julie A FieldsDepartment of Psychiatry and Psychology, Mayo Clinic, Rochester, MN 55905, USA.
Eduardo E BenarrochDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Val LoweDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Ronald C PetersenDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.
Bradley F BoeveDepartment of Neurology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-4153-8187
Kejal KantarciDepartment of Radiology, Mayo Clinic, Rochester, MN 55905, USA.ORCID https://orcid.org/0000-0002-8001-2081
Mayo Clinic · USMayo Clinic in Florida · USMayo Clinic in Arizona · US

Funding

SUPPLEMENT TO ALZHEIMERS DISEASE PATIENT REGISTRYU01AG006786 · NIA · MAYO CLINIC ROCHESTER · PI GRAFF-RADFORD, JONATHAN, JACK, CLIFFORD R. · 1986 to 2023
$49.6M
THE PGRN/TDP-43 AXIS IN ALZHEIMER?S DISEASE AND NEURODEGENERATIONP50AG016574 · NIA · MAYO CLINIC ROCHESTER · PI PETERSEN, RONALD C · 1999 to 2018
$36.9M
Research Education ComponentP30AG062677 · NIA · MAYO CLINIC ROCHESTER · PI NILUFER ERTEKIN-TANER · 2019 to 2026
$33.5M
Longitudinal Imaging Biomarkers of Prodromal DLBU01NS100620 · NINDS · MAYO CLINIC ROCHESTER · PI Bradley F Boeve, KEJAL KANTARCI · 2017 to 2026
$19.2M
Neuroprotective Treatment Trial Planning in REM Sleep Behavior DisorderR34AG056639 · NIA · WASHINGTON UNIVERSITY · PI BOEVE, BRADLEY F, JU, YO-EL S · 2018 to 2019
$1.2M
NIA NIH HHS P30 AG062677NIA NIH HHS P50 AG016574NIA NIH HHS R34 AG056639NIA NIH HHS U01 AG006786NINDS NIH HHS U01 NS100620
6 · The paper itself

Abstract

Alterations of cerebral glucose metabolism can be detected in patients with isolated rapid eye movement sleep behaviour disorder, a prodromal feature of neurodegenerative diseases with α-synuclein pathology. However, metabolic characteristics that determine clinical progression in isolated rapid eye movement sleep behaviour disorder and their association with other biomarkers need to be elucidated. We investigated the pattern of cerebral glucose metabolism on

Indexed as

FDGisolated REM sleep behaviour disorderLewy bodies diseasePETSPECT

Identifiers

PMID36844148
PMCPMC9945851
OpenAlexW4318897417

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.