Evidence map›Paper›PMID 36843940›Full record

ReviewFrontiers in pharmacology2023

Delayed revascularization in acute ischemic stroke patients.

T Marc Eastin, Justin A Dye, Promod Pillai, Miguel A Lopez-Gonzalez, Lei Huang, John H Zhang, Warren W Boling

Abstract readReview
In one paragraph

Review in Frontiers in pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

T Marc EastinDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.
Justin A DyeDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.
Promod PillaiDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.
Miguel A Lopez-GonzalezDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.
Lei HuangDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.
John H ZhangDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.
Warren W BolingDepartment of Neurological Surgery, Loma Linda University Medical Center, Loma Linda, CA, United States.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Stroke shares a significant burden of global mortality and disability. A significant decline in the quality of life is attributed to the so-called post-stroke cognitive impairment including mild to severe cognitive alterations, dementia, and functional disability. Currently, only two clinical interventions including pharmacological and mechanical thrombolysis are advised for successful revascularization of the occluded vessel. However, their therapeutic effect is limited to the acute phase of stroke onset only. This often results in the exclusion of a significant number of patients who are unable to reach within the therapeutic window. Advances in neuroimaging technologies have allowed better assessment of salvageable penumbra and occluded vessel status. Improvement in diagnostic tools and the advent of intravascular interventional devices such as stent retrievers have expanded the potential revascularization window. Clinical studies have demonstrated positive outcomes of delayed revascularization beyond the recommended therapeutic window. This review will discuss the current understanding of ischemic stroke, the latest revascularization doctrine, and evidence from clinical studies regarding effective delayed revascularization in ischemic stroke.

Indexed as

delayed revascularizationischemic strokepenumbrarevascularizationstrokethrombectomythrombolysis

Identifiers

PMID36843940
PMCPMC9945110

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.