Evidence map›Paper›PMID 36843839›Full record

ArticleiScience2023

Telomeres cooperate in zygotic genome activation by affecting

Xiaorui Zhang, Changquan Zhang, Di Zhou, Tianlei Zhang, Xueqin Chen, Jinlin Ren, Caixia He, Fei Meng, Qinwei Zhou, Qiaohui Yang and 4 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Review
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Xiaorui ZhangHospital of Hunan Guangxiu, Hunan Normal University, Hunan 410001, China.
Changquan ZhangNHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Di ZhouNHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Tianlei ZhangReproductive and Genetic Hospital of Citic-Xiangya, Hunan 410008, China.
Xueqin ChenNHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Jinlin RenHospital of Hunan Guangxiu, Hunan Normal University, Hunan 410001, China.
Caixia HeNHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Fei MengReproductive and Genetic Hospital of Citic-Xiangya, Hunan 410008, China.
Qinwei ZhouReproductive and Genetic Hospital of Citic-Xiangya, Hunan 410008, China.
Qiaohui YangNHC Key Laboratory of Human Stem and Reproductive Engineering, School of Basic Medical Science, Central South University, Changsha, China.
Congling DaiReproductive and Genetic Hospital of Citic-Xiangya, Hunan 410008, China.
Ge LinReproductive and Genetic Hospital of Citic-Xiangya, Hunan 410008, China.
Sicong ZengHospital of Hunan Guangxiu, Hunan Normal University, Hunan 410001, China.
Lizhi LengReproductive and Genetic Hospital of Citic-Xiangya, Hunan 410008, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Zygotic genome activation (ZGA) is initiated once the genome chromatin state is organized in the newly formed zygote. Telomeres are specialized chromatin structures at the ends of chromosomes and are reset during early embryogenesis, while the details and significance of telomere changes in preimplantation embryos remain unclear. We demonstrated that the telomere length was shortened in the minor ZGA stage and significantly elongated in the major ZGA stage of human and mouse embryos. Expression of the ZGA pioneer factor

Indexed as

Biological sciencesGeneticsGenomics

Identifiers

PMID36843839
PMCPMC9950522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.