Evidence map›Paper›PMID 36843572›Full record

ArticleChronic stress (Thousand Oaks, Calif.)

Nicotine Use and Metabotropic Glutamate Receptor 5 in Individuals With Major Depressive and Posttraumatic Stress Disorders.

Stephen R Baldassarri, Ruth H Asch, Ansel T Hillmer, Robert H Pietrzak, Nicole DellaGioia, Irina Esterlis, Margaret T Davis

Open access · goldAbstract read
In one paragraph

Article in Chronic stress (Thousand Oaks, Calif.). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Stephen R BaldassarriSection of Pulmonary, Critical Care, & Sleep Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0002-5928-3733
Ruth H AschDepartments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Ansel T HillmerDepartments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Robert H PietrzakDepartments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Nicole DellaGioiaDepartments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.
Irina EsterlisDepartments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-6293-1458
Margaret T DavisDepartments of Psychiatry, Yale University School of Medicine, New Haven, CT, USA.ORCID https://orcid.org/0000-0001-7297-710X
Yale University · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
RESEARCH TRAINING - BIOLOGICAL SCIENCEST32MH014276 · NIMH · YALE UNIVERSITY · PI Marina R Picciotto · 1985 to 2026
$7.2M
In vivo imaging of a neural marker of suicidal behavior in Bipolar DisorderR01MH116657 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA · 2019 to 2024
$4.0M
PET-fMRI Study of Glutamate and Frontal Function in Bi- and Uni-polar DepressionR01MH104459 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA · 2015 to 2019
$3.6M
Dysregulation in mGluR5 as a marker of BPD and suicide related endophenotypesK08MH117351 · NIMH · YALE UNIVERSITY · PI DAVIS, MARGARET TAYLOR · 2018 to 2022
$983k
Understanding Factors that Influence Electronic Cigarette Nicotine Delivery Through PET Imaging of Beta-2 Nicotinic Acetylcholine ReceptorsK23DA045957 · NIDA · YALE UNIVERSITY · PI BALDASSARRI, STEPHEN · 2018 to 2022
$983k
Multimodal Neuroimaging of Alcohol Withdrawal: The Role of Glutamate in Neural ReorganizationK01AA024788 · NIAAA · YALE UNIVERSITY · PI HILLMER, ANSEL · 2017 to 2021
$894k
Role of Beta2-nAChR in Bipolar DisorderK01MH092681 · NIMH · YALE UNIVERSITY · PI ESTERLIS, IRINA · 2011 to 2015
$850k
NCATS NIH HHS UL1 TR001863NIAAA NIH HHS K01 AA024788NIDA NIH HHS K23 DA045957NIMH NIH HHS K01 MH092681NIMH NIH HHS K08 MH117351NIMH NIH HHS L30 MH120754NIMH NIH HHS R01 MH104459NIMH NIH HHS R01 MH116657NIMH NIH HHS T32 MH014276
6 · The paper itself

Abstract

Metabotropic glutamate receptor 5 (mGluR5) dysregulation has been implicated in the pathophysiology of many psychiatric disorders, as well as nicotine use and dependence. We used positron emission tomography with [

Indexed as

depressionglutamateneuroimagingnicotineposttraumatic stress disorder

Identifiers

PMID36843572
PMCPMC9943964
OpenAlexW4319923619

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.