Evidence map›Paper›PMID 36843539›Full record

ArticleInternational journal of surgical pathology2023

Aberrant p53 Expression in Gastric Biopsies and Resection Specimens Following Neoadjuvant Chemoradiation: A Diagnostic Pitfall.

Danielle A Hutchings, Kevan J Salimian, Kevin M Waters, Jacqueline E Birkness-Gartman, Lysandra Voltaggio, Naziheh Assarzadegan, Jialing Huang, Ming-Tseh Lin, Aatur D Singhi, Elizabeth A Montgomery

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Article in International journal of surgical pathology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Danielle A HutchingsDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.ORCID 0000-0003-3188-0525
Kevan J SalimianDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Kevin M WatersDepartment of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
Jacqueline E Birkness-GartmanDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0002-1224-3304
Lysandra VoltaggioDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID 0000-0003-2611-7576
Naziheh AssarzadeganDepartment of Pathology, University of Michigan, Ann Arbor, MI, USA.
Jialing HuangDepartment of Pathology, Thomas Jefferson University, Philadelphia, PA, USA.
Ming-Tseh LinDepartment of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Aatur D SinghiDepartment of Pathology, University of Pittsburgh, Pittsburgh, PA, USA.
Elizabeth A MontgomeryDepartment of Pathology, University of Miami Miller School of Medicine, Miami, FL, USA.
Johns Hopkins University · USCedars-Sinai Medical Center · USThomas Jefferson University · USUniversity of Miami · USUniversity of Michigan · USUniversity of Pittsburgh · US

Funding

Opportunities for Pathology Trainees in Cancer ResearchT32CA193145 · NCI · JOHNS HOPKINS UNIVERSITY · PI ANDERS, ROBERT A., EBERHART, CHARLES G · 2015 to 2025
$2.6M
NCI NIH HHS T32 CA193145
6 · The paper itself

Abstract

Gastric mucosal biopsies and resections from patients treated with neoadjuvant radiation and/or chemotherapy are frequently encountered. These samples may show histologic features related to therapy including inflammation, ulceration, and epithelial atypia. In some cases, epithelial atypia may be marked, prompting the use of adjunct p53 immunohistochemistry. We examined p53 expression by immunohistochemistry in gastric mucosa following therapy. We evaluated the histology and p53 immunohistochemical expression in gastric mucosa from 5 We identified histomorphologic features of therapy-related epithelial changes in 50 of 60 cases (83%). Abnormal p53 expression was present at least focally in nearly half the cases (27 of 60 cases; 45%), all of which showed morphologic evidence of therapy-related epithelial changes Our results demonstrate that abnormal p53 expression is relatively common in gastric mucosal samples following radiation and/or chemotherapy and suggest that p53 expression should be avoided when distinguishing therapy

Indexed as

CarcinomaEsophageal NeoplasmsBiopsyHumansNeoadjuvant TherapyTumor Suppressor Protein p53Tumor Suppressor Protein p53carcinomadysplasiaesophagusimmunohistochemistryp53stomach

Identifiers

PMID36843539
PMCPMC10460459
OpenAlexW4322495743

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.