Evidence map›Paper›PMID 36843451›Full record

ArticleNeuro-oncology2023

Diagnosis and management of complications from the treatment of primary central nervous system tumors in adults.

Michael Weller, Emilie Le Rhun, Martin Van den Bent, Susan M Chang, Timothy F Cloughesy, Roland Goldbrunner, Yong-Kil Hong, Rakesh Jalali, Michael D Jenkinson, Giuseppe Minniti and 8 more

Open access · hybridAbstract read
In one paragraph

Article in Neuro-oncology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
12.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 1 synthesis or guideline pooled it, 45 citations in OpenAlex.

  1. Pooled it
  2. Obstacles and Trials in Treating Primary Brain Tumors.International journal of molecular sciences · 2026
    Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
  8. Mapping integrated care for brain tumour-related epilepsy in the Italian RIN-IRCCS network.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Frontiers in immunology · 2026
    Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 16 institutions in 11 countries.

Michael WellerDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.ORCID 0000-0002-1748-174X
Emilie Le RhunDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Martin Van den BentThe Brain Tumour Center at the Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Susan M ChangDepartment of Neurological Surgery, University of California, San Francisco, California, USA.
Timothy F CloughesyDepartment of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.
Roland GoldbrunnerCenter of Neurosurgery, Department of General Neurosurgery, University of Cologne, Cologne, Germany.
Yong-Kil HongBrain Tumor Center, Hallym University Sacred Heart Hospital, Anyang, South Korea.
Rakesh JalaliNeuro Oncology Cancer Management Team, Apollo Proton Cancer Centre, Chennai, India.
Michael D JenkinsonDepartment of Neurosurgery, The Walton Centre NHS Foundation Trust & University of Liverpool, Liverpool, UK.
Giuseppe MinnitiDepartment of Medicine, Surgery and Neurosciences, University of Siena, Policlinico Le Scotte, Siena, Italy.
Motoo NaganeDepartment of Neurosurgery, Kyorin University Faculty of Medicine, Tokyo, Japan.ORCID 0000-0002-0018-1652
Evangelia RazisThird Department of Medical Oncology, Hygeia Hospital, Marousi, Athens, Greece.
Patrick RothDepartment of Neurology, University Hospital and University of Zurich, Zurich, Switzerland.
Roberta RudàDivision of Neuro-Oncology, Department of Neuroscience, City of Health and Science and University of Turin, Turin, Italy.
Ghazaleh TabatabaiDepartment of Neurology & Neuro-Oncology, Hertie Institute for Clinical Brain Research, Center for Neurooncology, Comprehensive Cancer Center, German Cancer Consortium (DKTK), Partner site Tübingen, University Hospital Tübingen, Eberhard Karls University Tübingen, Tübingen, Germany.ORCID 0000-0002-3542-8782
Patrick Y WenCenter for Neuro-oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts, USA.
Susan C ShortLeeds Institute of Medical Research, University of Leeds, Leeds, UK.
Matthias PreusserDivision of Oncology, Department of Medicine 1, Medical University, Vienna, Austria.ORCID 0000-0003-3541-2315
University of Zurich · CHApollo Proton Cancer Centre · INErasmus MC Cancer Institute · NLHallym University Sacred Heart Hospital · KRHarvard University · USHertie Institute for Clinical Brain Research · DEHygeia Hospital · GRKyorin University · JPMedical University of Vienna · ATUniversity of California, Los Angeles · USUniversity of California, San Francisco · USUniversity of Cologne · DEUniversity of Leeds · GBUniversity of Liverpool · GBUniversity of Siena · ITUniversity of Turin · IT

Funding

UCLA SPORE in Brain CancerP50CA211015 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Yvonne Yu-Hsuan Chen · 2017 to 2026
$25.2M
NCI NIH HHS P50 CA211015
6 · The paper itself

Abstract

Central nervous system (CNS) tumor patients commonly undergo multimodality treatment in the course of their disease. Adverse effects and complications from these interventions have not been systematically studied, but pose significant challenges in clinical practice and impact function and quality of life, especially in the management of long-term brain tumor survivors. Here, the European Association of Neuro-Oncology (EANO) has developed recommendations to prevent, diagnose, and manage adverse effects and complications in the adult primary brain CNS tumor (except lymphomas) patient population with a specific focus on surgery, radiotherapy, and pharmacotherapy. Specifically, we also provide recommendations for dose adaptations, interruptions, and reexposure for pharmacotherapy that may serve as a reference for the management of standard of care in clinical trials. We also summarize which interventions are unnecessary, inactive or contraindicated. This consensus paper should serve as a reference for the conduct of standard therapy within and outside of clinical trials.

Indexed as

Brain NeoplasmsCentral Nervous System NeoplasmsLymphomaAdultCombined Modality TherapyHumansQuality of Lifeadverse affectsdoseinterruptionspreventionreexposuretoxicity

Identifiers

PMID36843451
PMCPMC10326495
OpenAlexW4322491469

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.