Evidence map›Paper›PMID 36843434›Full record

ReviewJournal of leukocyte biology2023

Metabolic regulation of NK cell antiviral functions during cytomegalovirus infection.

Maria Cimpean, Megan A Cooper

Open access · bronzeAbstract readReview
In one paragraph

Review in Journal of leukocyte biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Immunology of Cytokine Storm Syndromes: Natural Killer Cells.Advances in experimental medicine and biology · 2024
    Review
  5. Nutrient transporter pattern in CD56Frontiers in immunology · 2024
    Article
  6. IL-15 Priming Alters IFN-γ Regulation in Murine NK Cells.Journal of immunology (Baltimore, Md. : 1950) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Maria CimpeanDepartment of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis, 660 S. Euclid Ave, Box 8208, St. Louis, MO 63110, United States.ORCID 0000-0003-3735-2643
Megan A CooperDepartment of Pediatrics, Division of Rheumatology/Immunology, Washington University in St. Louis, 660 S. Euclid Ave, Box 8208, St. Louis, MO 63110, United States.ORCID 0000-0002-5696-172X
Washington University in St. Louis · US

Funding

METABOLIC REGULATION OF NATURAL KILLER CELL ACTIVATIONR01AI127752 · NIAID · WASHINGTON UNIVERSITY · PI COOPER, MEGAN ANNE · 2017 to 2021
$1.9M
Metabolic Regulation of Natural Killer Cell ActivationR56AI127752 · NIAID · WASHINGTON UNIVERSITY · PI COOPER, MEGAN ANNE · 2023 to 2023
$300k
NIAID NIH HHS R01 AI127752NIAID NIH HHS R56 AI127752
6 · The paper itself

Abstract

Natural killer (NK) cells quickly mount cytotoxic responses, produce cytokines, and proliferate in response to infected or transformed cells. Moreover, they can develop memory, with enhanced effector responses following activation, in some cases with antigen specificity. To optimally execute these functions, NK cells undergo metabolic reprogramming. Here, we discuss the interplay between metabolism and NK cell function in the context of viral infections. We review findings supporting metabolic regulation of NK cell effector functions, with a focus on NK cell antiviral infection in the context of cytomegalovirus in the mouse (MCMV) and human (HCMV).

Indexed as

Antiviral AgentsCytomegalovirus InfectionsAnimalsCytokinesCytomegalovirusHumansKiller Cells, NaturalMiceAntiviral AgentsCytokinescytokinescytomegalovirus infectioncytotoxicityinterferon gammamemorymetabolismnatural killer cellsproliferation

Identifiers

PMID36843434
PMCPMC11262056
OpenAlexW4322500256

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.