Evidence map›Paper›PMID 36843128›Full record

ArticleNaunyn-Schmiedeberg's archives of pharmacology2023

Doxycycline inhibits dopaminergic neurodegeneration through upregulation of axonal and synaptic proteins.

Lilian do Amaral, Neife Aparecida Guinaim Dos Santos, Flávia Malvestio Sisti, Elaine Del Bel, Antônio Cardozo Dos Santos

Abstract read
PubMed Publisher
In one paragraph

Article in Naunyn-Schmiedeberg's archives of pharmacology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Article
  3. Microbiome-based therapeutics for Parkinson's disease.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Lilian do AmaralDepartment of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, Av Do Café S/N, University of São Paulo, Ribeirão Preto, SP, 14040-903, Brazil.
Neife Aparecida Guinaim Dos SantosDepartment of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, Av Do Café S/N, University of São Paulo, Ribeirão Preto, SP, 14040-903, Brazil.
Flávia Malvestio SistiDepartment of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, Av Do Café S/N, University of São Paulo, Ribeirão Preto, SP, 14040-903, Brazil.
Elaine Del BelDepartment of Basic and Oral Biology, Faculty of Dentistry of Ribeirão Preto, USP, Av Do Café S/N, 14040-904, Ribeirão Preto, SP, Brazil.
Antônio Cardozo Dos SantosDepartment of Clinical, Toxicological and Bromatological Analysis, School of Pharmaceutical Sciences of Ribeirão Preto, Av Do Café S/N, University of São Paulo, Ribeirão Preto, SP, 14040-903, Brazil. acsantos@fcfrp.usp.br.
Universidade de São Paulo · BR

Funding

CNPq 305823/2019-1
6 · The paper itself

Abstract

Doxycycline (DOX) is a widely used antibiotic that is able to cross the blood-brain barrier. Several studies have shown its neuroprotective effect against neurodegeneration and have associated it with antioxidant, anti-apoptotic, and anti-inflammatory mechanisms. We have recently demonstrated that DOX mimics nerve growth factor (NGF) signaling in PC12 cells. However, the involvement of this mechanism in the neuroprotective effect of DOX is unknown. Axonal degeneration and synaptic loss are key events at the early stages of neurodegeneration, and precede the neuronal death in neurodegenerative diseases, including Parkinson's disease (PD). Therefore, the regeneration of the axonal and synaptic network might be beneficial in PD. The effect of DOX in PC12 cells treated with the Parkinsonian neurotoxin 1-methyl-4-phenylpyridinium (MPP

Indexed as

Neuroprotective AgentsParkinson Disease1-Methyl-4-phenylpyridiniumAnimalsDoxycyclineHumansNerve Growth FactorPC12 CellsProteinsRatsTubulinUp-Regulation1-Methyl-4-phenylpyridiniumDoxycyclineNerve Growth FactorNeuroprotective AgentsProteinsTubulin1-Methyl-4-phenylpyridinium (MPP+)Axonal plasticityDoxycyclineNeuroprotectionParkinson’s diseasePC12 cells

Identifiers

PMID36843128
OpenAlexW4322201910

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.