ArticleContemporary clinical trials2023
Keep It Up! 3.0: Study protocol for a type III hybrid implementation-effectiveness cluster-randomized trial.
Article in Contemporary clinical trials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
13 citing papers in PubMed.
- Comparing Implementation and Effectiveness Outcomes for Two Implementation Strategies of the Keep It Up! Digital HIV Prevention Program: A Type 3 Hybrid Effectiveness-Implementation Trial.AIDS and behavior · 2025Trial
- Behavioral Efficacy of a Sexual Health Mobile App for Men Who Have Sex With Men: Randomized Controlled Trial of Mobile Messaging for Men.Journal of medical Internet research · 2022Trial
- Towards a Better Understanding of HIV Prevention Knowledge Among Latino MSM: A Latent Class Analysis Study.AIDS and behavior · 2026Article
- When scientific constraints and real-world implementation collide: Lessons from a hybrid type 3 study of a digital, direct-to-consumer HIV prevention program.Research square · 2026Article
- Incentivizing Prevention: Community Based Organizations' Perceptions on Financial Incentives for Recruitment and Retention of Participants in Keep it Up! (KIU!), an eHealth HIV Prevention Intervention.AIDS and behavior · 2026Article
- Community-Based Organizations' Approaches to Recruitment and Retention for a Digital HIV Prevention Intervention for Young Men Who Have Sex With Men: A Mixed Methods Study.Journal of medical Internet research · 2025Article
- Maintain the gains: methods to evaluate the sustainability and scalability of HIV-related prevention, care, and treatment programs.Current opinion in HIV and AIDS · 2025Review
- Considerations for evaluating pragmatic design elements in digital health intervention trials: the case of Keep It Up! 3.0.Implementation science communications · 2025Article
- Substance Use Classes Among YMSM in an HIV Digital Health Intervention Program: Implications for Acceptability, Engagement, and Health Outcomes.AIDS and behavior · 2025Article
- Barriers and Facilitators to Implementing Keep It Up!, A Digital Health Intervention, in Community-Based Organizations.AIDS and behavior · 2024Article
- A mixed-methods approach to assessing implementers' readiness to adopt digital health interventions (RADHI).Implementation science communications · 2024Article
- "Your Package Could Not Be Delivered": The State of Digital HIV Intervention Implementation in the US.Current HIV/AIDS reports · 2024Review
- Explorations of the Role of Digital Technology in HIV-Related Implementation Research: Case Comparisons of Five Ending the HIV Epidemic Supplement Awards.Journal of acquired immune deficiency syndromes (1999) · 2022Article
Corrections and comments
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Authors and funding
17 authors.
Funding
Abstract
backgroundDespite evidence that eHealth approaches can be effective in reducing HIV risk, their implementation requirements for public health scale up are not well established, and effective strategies to bring these programs into practice are still unknown. Keep It Up! (KIU!) is an online program proven to reduce HIV risk among young men who have sex with men (YMSM) and ideal candidate to develop and evaluate novel strategies for implementing eHealth HIV prevention programs. KIU! 3.0 is a Type III Hybrid Effectiveness-Implementation cluster randomized trial designed to 1) compare two strategies for implementing KIU!: community-based organizations (CBO) versus centralized direct-to-consumer (DTC) recruitment; 2) examine the effect of strategies and determinants on variability in implementation success; and 3) develop materials for sustainment of KIU! after the trial concludes. In this article, we describe the approaches used to achieve these aims.
methodsUsing county-level population estimates of YMSM, 66 counties were selected and randomized 2:1 to the CBO and DTC approaches. The RE-AIM model was used to drive outcome measurements, which were collected from CBO staff, YMSM, and technology providers. Mixed-methods research mapped onto the domains of the Consolidated Framework for Implementation Research will examine determinants and their relationship with implementation outcomes. DISCUSSION: In comparing our implementation recruitment models, we are examining two strategies which have shown effectiveness in delivering health technology interventions in the past, yet little is known about their comparative advantages and disadvantages in implementation. The results of the trial will further the understanding of eHealth prevention intervention implementation.
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