Evidence map›Paper›PMID 36842668›Full record

ArticleSLAS discovery : advancing life sciences R & D2023

High throughput assay for compounds that boost BDNF expression in neurons.

Guey-Ying Liao, Haifei Xu, Justin Shumate, Louis Scampavia, Timothy Spicer, Baoji Xu

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in SLAS discovery : advancing life sciences R & D, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.7field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 5 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Guey-Ying LiaoDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Haifei XuDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Justin ShumateDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Louis ScampaviaDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Timothy SpicerDepartment of Molecular Medicine, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, 130 Scripps Way, Jupiter, FL 33458, USA.
Baoji XuDepartment of Neuroscience, The Herbert Wertheim UF Scripps Institute for Biomedical Innovation & Technology, University of Florida, 130 Scripps Way, Jupiter, FL 33458, USA. Electronic address: baoji.xu@ufl.edu.
University of Florida · USScripps Institution of Oceanography · USScripps Research Institute · US

Funding

TrkB Neurons in the Control of Body WeightR01DK105954 · NIDDK · UNIVERSITY OF FLORIDA · PI XU, BAOJI · 2016 to 2022
$4.6M
Unraveling the Role of PVH BDNF Neurons in Energy BalanceR01DK103335 · NIDDK · UNIVERSITY OF FLORIDA · PI XU, BAOJI · 2015 to 2022
$4.4M
Molecular and cellular basis for autism spectrum disorders caused by exacerbated translationR01MH125187 · NIMH · UNIVERSITY OF FLORIDA · PI RUMBAUGH, GAVIN R, XU, BAOJI · 2020 to 2024
$2.7M
Integrated Acoustic Transfer System for HTS Library ManagementS10OD025279 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2018 to 2018
$624k
Tandem Multi-modal Plate Readers for a High Throughput Screening platformS10OD030330 · OD · UNIVERSITY OF FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2021 to 2021
$600k
HTS Drug  Discovery DispensersS10OD026857 · OD · SCRIPPS FLORIDA · PI SCAMPAVIA, LOUIS DANIEL · 2019 to 2019
$452k
NIDDK NIH HHS R01 DK103335NIDDK NIH HHS R01 DK105954NIH HHS S10 OD025279NIH HHS S10 OD026857NIH HHS S10 OD030330NIMH NIH HHS R01 MH125187
6 · The paper itself

Abstract

Deficiencies in brain-derived neurotrophic factor (BDNF) have been linked to several brain disorders, making compounds that can boost neuronal BDNF synthesis attractive as potential therapeutics. However, a sensitive and quantitative BDNF assay for high-throughput screening (HTS) is still missing. Here we report the generation of a new mouse Bdnf allele, Bdnf

Indexed as

Brain-Derived Neurotrophic FactorHigh-Throughput Screening AssaysAnimalsBrainCalcium Channels, L-TypeMiceNeuronsBrain-Derived Neurotrophic FactorCalcium Channels, L-TypeBrain-derived neurotrophic factorGene expressionHTS assayKnockinLOPAC libraryNano luciferase

Identifiers

PMID36842668
PMCPMC10759152
OpenAlexW4322008063

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.