Evidence map›Paper›PMID 36842420›Full record

ArticleJournal of colloid and interface science2023

Nanoarchitectonics of nitric oxide releasing supramolecular structures for enhanced antibacterial efficacy under visible light irradiation.

Anil Kumar, Arnab Mondal, Megan E Douglass, Divine J Francis, Mark R Garren, Lori M Estes Bright, Sama Ghalei, Jin Xie, Elizabeth J Brisbois, Hitesh Handa

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of colloid and interface science, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 14 citations in OpenAlex.

  1. Porphyrin-Based Porous Materials for Antibacterial Applications.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Anil KumarSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Arnab MondalSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Megan E DouglassSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Divine J FrancisDepartment of Chemistry, University of Georgia, Athens, GA 30602, United States.
Mark R GarrenSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Lori M Estes BrightSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Sama GhaleiSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Jin XieDepartment of Chemistry, University of Georgia, Athens, GA 30602, United States.
Elizabeth J BrisboisSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States.
Hitesh HandaSchool of Chemical Materials and Biomedical Engineering, University of Georgia, Athens, GA 30602, United States. Electronic address: hhanda@uga.edu.
University of Georgia · US

Funding

Engineering nitric oxide releasing polymer with immobilized thrombin inhibitor for blood contacting applicationsR01HL134899 · NHLBI · UNIVERSITY OF GEORGIA · PI HANDA, HITESH · 2017 to 2025
$3.0M
Heparin-free extracorporeal circulation via combined nitric oxide releasing/generating surfacesR01HL157587 · NHLBI · UNIVERSITY OF GEORGIA · PI BRISBOIS, ELIZABETH JOY · 2021 to 2024
$1.5M
NHLBI NIH HHS R01 HL134899NHLBI NIH HHS R01 HL157587
6 · The paper itself

Abstract

Light-controlled therapies offer a promising strategy to prevent and suppress infections caused by numerous bacterial pathogens. Excitation of exogenously supplied photosensitizers (PS) at specific wavelengths elicits levels of reactive oxygen intermediates toxic to bacteria. Porphyrin-based supramolecular nanostructure frameworks (SNF) are effective PS with unique physicochemical properties that have led to their widespread use in photomedicine. Herein, we developed a nitric oxide (NO) releasing, biocompatible, and stable porphyrin-based SNF (SNF-NO), which was achieved through a confined noncovalent self-assembly process based on π-π stacking. Characterization of the SNFs via scanning electron microscopy (SEM) and transmission electron microscopy (TEM) analysis showed the formation of three-dimensional, well-defined octahedral structures. These SNF-NO were shown to exhibit a red shift due to the noncovalent self-assembly of porphyrins, which also show extended light absorption to broadly cover the entire visible light spectrum to enhance photodynamic therapy (PDT). Under visible light irradiation (46 J cm

Indexed as

Methicillin-Resistant Staphylococcus aureusPhotochemotherapyPorphyrinsAnimalsAnti-Bacterial AgentsEscherichia coliLightMammalsNitric OxidePhotosensitizing AgentsAnti-Bacterial AgentsNitric OxidePhotosensitizing AgentsPorphyrinsAntibacterialBacterial respirationBiocompatibleBiofilmBiomedical applicationNanoarchitectonicsNanostructureNitric oxidePhotosensitizerReactive oxygen speciesSupramolecular

Identifiers

PMID36842420
PMCPMC10081829
OpenAlexW4321378918

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.