ArticleJournal of biomechanics2023
Pulse wave imaging of a stenotic artery model with plaque constituents of different stiffnesses: Experimental demonstration in phantoms and fluid-structure interaction simulation.
Article in Journal of biomechanics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed, 9 citations in OpenAlex.
- Noninvasive Assessment of Arterial Compliance and Lumen Pressure in Human Carotid Arteries Using Physics-Informed Neural Networks and Ultrasound Imaging: A Clinical Feasibility Study.Research square · 2026Article
- Assessment of Spatially-Varying Arterial Wall Stiffness and Pressure Using a Physics-Informed Neural Network and Pulse Wave Imaging: An in Silico and Experimental Phantom Study of Stenotic Vessels.Ultrasound in medicine & biology · 2026Article
- Polyvinyl Alcohol Phantoms With Heterogeneous Plaques: Estimation of Pulse Wave Velocity at the Stenotic Region Using Pulse Wave Imaging.Ultrasound in medicine & biology · 2024Article
- Unsupervised deep learning-based displacement estimation for vascular elasticity imaging applications.Physics in medicine and biology · 2023Article
- Modeling Dynamics of the Cardiovascular System Using Fluid-Structure Interaction Methods.Biology · 2023Review
- Characteristics and evaluation of atherosclerotic plaques: an overview of state-of-the-art techniques.Frontiers in neurology · 2023Review
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Vulnerable plaques associated with softer components may rupture, releasing thrombotic emboli to smaller vessels in the brain, thus causing an ischemic stroke. Pulse Wave Imaging (PWI) is an ultrasound-based method that allows for pulse wave visualization while the regional pulse wave velocity (PWV) is mapped along the arterial wall to infer the underlying wall compliance. One potential application of PWI is the non-invasive estimation of plaque's mechanical properties for investigating its vulnerability. In this study, the accuracy of PWV estimation in stenotic vessels was investigated by computational simulation and PWI in validation phantoms to evaluate this modality for assessing future stroke risk. Polyvinyl alcohol (PVA) phantoms with plaque constituents of different stiffnesses were designed and constructed to emulate stenotic arteries in the experiment, and the novel fabrication process was described. Finite-element fluid-structure interaction simulations were performed in a stenotic phantom model that matched the geometry and parameters of the experiment in phantoms. The peak distension acceleration of the phantom wall was tracked to estimate PWV. PWVs of 2.57 ms
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.