Evidence map›Paper›PMID 36842339›Full record

ArticleBiomaterials2023

Matching mechanical heterogeneity of the native spinal cord augments axon infiltration in 3D-printed scaffolds.

Kiet A Tran, Brandon J DeOre, David Ikejiani, Kristen Means, Louis S Paone, Laura De Marchi, Łukasz Suprewicz, Katarina Koziol, Julien Bouyer, Fitzroy J Byfield and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomaterials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
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  4. Targeting Fibrotic Scarring by Mechanoregulation of Il11ra1Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Kiet A TranDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ, USA.
Brandon J DeOreDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ, USA.
David IkejianiDepartment of Bioengineering, Rice University, Houston, TX, USA.
Kristen MeansDepartment of Bioengineering, Rice University, Houston, TX, USA.
Louis S PaoneDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ, USA.
Laura De MarchiDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ, USA.
Łukasz SuprewiczDepartment of Medical Microbiology and Nanobiomedical Engineering, Medical University of Bialystok, Bialystok, Poland.
Katarina KoziolDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ, USA.
Julien BouyerDepartment of Neurobiology and Anatomy, Drexel College of Medicine, Philadelphia, PA, USA.
Fitzroy J ByfieldDepartment of Physiology, University of Pennsylvania, Philadelphia, PA, USA.
Ying JinDepartment of Neurobiology and Anatomy, Drexel College of Medicine, Philadelphia, PA, USA.
Penelope GeorgesCouncil on Science and Technology, Princeton University, Princeton, NJ, USA.
Itzhak FischerDepartment of Neurobiology and Anatomy, Drexel College of Medicine, Philadelphia, PA, USA.
Paul A JanmeyDepartment of Physiology, University of Pennsylvania, Philadelphia, PA, USA.
Peter A GalieDepartment of Biomedical Engineering, Rowan University, Glassboro, NJ, USA. Electronic address: galie@rowan.edu.

Funding

Regulation of cell, tissue, and nucleus function by mechanical properties of biopolymer networksR35GM136259 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI Paul A Janmey · 2020 to 2026
$3.2M
NIGMS NIH HHS R35 GM136259
6 · The paper itself

Abstract

Scaffolds delivered to injured spinal cords to stimulate axon connectivity often match the anisotropy of native tissue using guidance cues along the rostral-caudal axis, but current approaches do not mimic the heterogeneity of host tissue mechanics. Although white and gray matter have different mechanical properties, it remains unclear whether tissue mechanics also vary along the length of the cord. Mechanical testing performed in this study indicates that bulk spinal cord mechanics do differ along anatomical level and that these differences are caused by variations in the ratio of white and gray matter. These results suggest that scaffolds recreating the heterogeneity of spinal cord tissue mechanics must account for the disparity between gray and white matter. Digital light processing (DLP) provides a means to mimic spinal cord topology, but has previously been limited to printing homogeneous mechanical properties. We describe a means to modify DLP to print scaffolds that mimic spinal cord mechanical heterogeneity caused by variation in the ratio of white and gray matter, which improves axon infiltration compared to controls exhibiting homogeneous mechanical properties. These results demonstrate that scaffolds matching the mechanical heterogeneity of white and gray matter improve the effectiveness of biomaterials transplanted within the injured spinal cord.

Indexed as

Spinal Cord InjuriesAxonsBiocompatible MaterialsHumansPrinting, Three-DimensionalSpinal CordTissue ScaffoldsBiocompatible Materials3D-printingAxon regenerationDigital light processingRheologySpinal cord injuryTissue engineering

Identifiers

PMID36842339
PMCPMC10292106

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.