ReviewJournal of neural transmission (Vienna, Austria : 1996)2023
Hemispheric asymmetries in mental disorders: evidence from rodent studies.
Review in Journal of neural transmission (Vienna, Austria : 1996), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- The Role of Anterior Insular Parvalbumin GABAergic Interneurons in Impulsivity-Related and Alcohol-Seeking Behaviors.CNS neuroscience & therapeutics · 2026Article
- TheFoods (Basel, Switzerland) · 2026Article
- Paw Preference in Rats Across Tests, Strains, Sex, and Age: A PRISMA-Compliant Systematic Review and Meta-Analysis.bioRxiv : the preprint server for biology · 2026Article
- Rigorous Validation of Paw Preference Using Three Complementary Behavioral Assays in Sprague Dawley Rats.bioRxiv : the preprint server for biology · 2026Article
- Neuropeptides in control of left-right neural circuits.Trends in neurosciences · 2026Review
- Beyond the auditory: anxiety bridges sleep disturbances and depressive symptoms to tinnitus handicap.Frontiers in psychiatry · 2026Article
- Looking at Both Sides: Integrating Data From Both Hemispheres Is Crucial in Rodent Neuroscience.The European journal of neuroscience · 2025Review
- Handedness in schizophrenia and affective disorders: a large-scale cross-disorder study.European archives of psychiatry and clinical neuroscience · 2025Article
- The Balance in the Head: How Developmental Factors Explain Relationships Between Brain Asymmetries and Mental Diseases.Brain sciences · 2025Review
- From Wings to Wellness: A Research Agenda Inspired by Migratory Bird Adaptations for Sleep and Circadian Medicine.Nature and science of sleep · 2025Article
- Alteration of hippocampal parvalbumin interneurons underlies memory impairment in rat model of Parkinson's disease.Frontiers in behavioral neuroscience · 2025Article
- Schismogenesis in anxiety spectrum disorders: a biopsychosocial perspective.Frontiers in psychiatry · 2025Article
- Hemispheric Asymmetry of Intracortical Myelin Orientation in the Mouse Auditory Cortex.The European journal of neuroscience · 2025Article
- Perinatal adversities as a common factor underlying the association between atypical laterality and neurodevelopmental disorders: A developmental perspective.Psychophysiology · 2024Review
- Oligodendrocyte progenitor cells' fate after neonatal asphyxia-Puzzling implications for the development of hypoxic-ischemic encephalopathy.Brain pathology (Zurich, Switzerland) · 2024Article
- Novel pharmacological targets for GABAergic dysfunction in ADHD.Neuropharmacology · 2024Review
- Lateralization of the 5-HTAmino acids · 2024Article
- Quantitative EEG and its relationship with attentional control in patients with anxiety disorders.Frontiers in psychiatry · 2024Article
- The Abnormal N-Acetylaspartate to Creatine Ratio of the Right Putamen is Linked to Wakefulness in Patients with Insomnia Disorder.Nature and science of sleep · 2024Article
- Behavioral lateralization in bipolar disorders: a systematic review.International journal of bipolar disorders · 2023Review
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The brain is built with hemispheric asymmetries in structure and function to enable fast neuronal processing. In neuroimaging studies, several mental disorders have been associated with altered or attenuated hemispheric asymmetries. However, the exact mechanism linking asymmetries and disorders is not known. Here, studies in animal models of mental disorders render important insights into the etiology and neuronal alterations associated with both disorders and atypical asymmetry. In this review, the current literature of animal studies in rats and mice focusing on anxiety and fear, anhedonia and despair, addiction or substance misuse, neurodegenerative disorders as well as stress exposure, and atypical hemispheric asymmetries is summarized. Results indicate overall increased right-hemispheric neuronal activity and a left-sided behavioral bias associated with symptoms of anxiety, fear, anhedonia, behavioral despair as well as stress exposure. Addiction behavior is associated with right-sided bias and transgenic models of Alzheimer's disease indicate an asymmetrical accumulation of fibrillar plaques. Most studies focused on changes in the bilateral amygdala and frontal cortex. Across studies, two crucial factors influencing atypical asymmetries arose independently of the disorder modeled: sex and developmental age. In conclusion, animal models of mental disorders demonstrate atypical hemispheric asymmetries similar to findings in patients. Particularly, increased left-sided behavior and greater right-hemispheric activity were found across models applying stress-based paradigms. However, sex- and age-dependent effects on atypical hemispheric asymmetries are present that require further investigation. Animal models enable the analysis of hemispheric changes on the molecular level which may be most effective to detect early alterations.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.