ArticlePediatric research2023
Prenatal and perinatal factors associated with neonatal neurobehavioral profiles in the ECHO Program.
Article in Pediatric research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03061890 (Developmental Impact of Neonatal Intensive Care Unit), which is not on this map. Cited by 13 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Developmental Impact of Neonatal Intensive Care Unit (NICU) Exposures: Environmental Influences on Child Health Outcomes (ECHO)
Who cites it
13 citing papers in PubMed.
- Associations between maternal emotion dysregulation, infant negative affect and toddler mental health depend on newborn neurobehavioral profiles.Clinical psychological science : a journal of the Association for Psychological Science · 2026Article
- Association between NNNS-II profiles and pharmacological treatment in infants with prenatal opioid exposure.Journal of perinatology : official journal of the California Perinatal Association · 2026Article
- Association between NNNS-II Profiles and Pharmacological Treatment in Infants with Prenatal Opioid Exposure.Research square · 2025Article
- Maternal perinatal depression and infant self-regulation: A meta-analytic review.Development and psychopathology · 2025Review
- Neurobehavioral Profiles in Opioid-Exposed and Unexposed Neonates.The Journal of pediatrics · 2025Observational
- Abnormal neurobehavior profiles observed in the newborn period following low-to-moderate prenatal alcohol exposure.Alcohol, clinical & experimental research · 2025Article
- Neurobehavioral outcomes of preterm infants: toward a holistic approach.Pediatric research · 2025Review
- Optimal presence: enhancing parent integration to maximize neurodevelopmental outcomes in preterm infants.Pediatric research · 2024Review
- Maternal symptoms of depression and anxiety as modifiers of the relationship between prenatal phthalate exposure and infant neurodevelopment in the Atlanta African American maternal-child cohort.Brain, behavior, & immunity - health · 2024Article
- Preeclampsia, Fetal Growth Restriction, and 24-Month Neurodevelopment in Very Preterm Infants.JAMA network open · 2024Article
- Maternal Racial Differences and Socioeconomic Status in Preterm Infant Neurodevelopment, Feeding, and Growth.Nursing researchArticle
- Associations of prenatal tobacco and insecticide co-exposures with neurobehavioral responses among children born to pregnant women exposed to cannabis.Neurotoxicology and teratologyArticle
- Prenatal buprenorphine/naloxone exposure and neonatal neurobehavioral functioning: A preliminary report.Neurotoxicology and teratologyArticle
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Authors and funding
25 authors.
Funding
Abstract
backgroundSingle-cohort studies have identified distinct neurobehavioral profiles that are associated with prenatal and neonatal factors based on the NICU Network Neurobehavioral Scale (NNNS). We examined socioeconomic, medical, and substance use variables as predictors of NNNS profiles in a multi-cohort study of preterm and term-born infants with different perinatal exposures.
methodsWe studied 1112 infants with a neonatal NNNS exam from the Environmental influences on Child Health Outcomes (ECHO) consortium. We used latent profile analysis to characterize infant neurobehavioral profiles and generalized estimating equations to determine predictors of NNNS profiles.
resultsSix distinct neonatal neurobehavioral profiles were identified, including two dysregulated profiles: a hypo-aroused profile (16%) characterized by lethargy, hypotonicity, and nonoptimal reflexes; and a hyper-aroused profile (6%) characterized by high arousal, excitability, and stress, with low regulation and poor movement quality. Infants in the hypo-aroused profile were more likely to be male, have younger mothers, and have mothers who were depressed prenatally. Infants in the hyper-aroused profile were more likely to be Hispanic/Latino and have mothers who were depressed or used tobacco prenatally.
conclusionsWe identified two dysregulated neurobehavioral profiles with distinct perinatal antecedents. Further understanding of their etiology could inform targeted interventions to promote positive developmental outcomes. IMPACT: Prior research on predictors of neonatal neurobehavior have included single-cohort studies, which limits generalizability of findings. In a multi-cohort study of preterm and term-born infants, we found six distinct neonatal neurobehavioral profiles, with two profiles being identified as dysregulated. Hypo- and hyper-aroused neurobehavioral profiles had distinct perinatal antecedents. Understanding perinatal factors associated with dysregulated neurobehavior could help promote positive developmental outcomes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.