Evidence map›Paper›PMID 36841266›Full record

ArticleThe Journal of allergy and clinical immunology2023

Lung dopaminergic nerves facilitate the establishment of T

Wei Wang, Carolyn Garcia, Fengzhi Shao, Jonathan A Cohen, Yan Bai, Alan Fine, Xingbin Ai

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of allergy and clinical immunology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. The immunology of asthma.Nature immunology · 2025
    Review
  5. Neuroimmune Circuits in Allergic Diseases.Annual review of immunology · 2025
    Review
  6. Review
  7. Review
  8. Update on type 2 immunity.The Journal of allergy and clinical immunology · 2025
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Wei WangDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Mass. Electronic address: wwang@mgh.harvard.edu.
Carolyn GarciaDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
Fengzhi ShaoPulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Mass.
Jonathan A CohenDivision of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Mass.
Yan BaiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Mass.
Alan FinePulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, Mass.
Xingbin AiDivision of Newborn Medicine, Department of Pediatrics, Massachusetts General Hospital, Boston, Mass. Electronic address: xai@partners.org.
Massachusetts General Hospital · USBoston University · USBrigham and Women's Hospital · US

Funding

Biology of Lymphangiogenesis in the Adult LungR01HL164612 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI JONES, MATTHEW ROBERT · 2022 to 2025
$2.3M
Age-related mechanisms of T helper 2 memory in the early lungR01HL154549 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AI, XINGBIN · 2021 to 2024
$2.2M
Origins and functional roles of Miwi2-positive multiciliated cells during inflammationR01HL136725 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI FINE, ALAN FINE, JONES, MATTHEW ROBERT · 2018 to 2021
$1.6M
Cholinergic hyperinnernation in early life regulates long-term airway reactivityK08HL135443 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BAI, YAN · 2017 to 2021
$861k
NHLBI NIH HHS K08 HL135443NHLBI NIH HHS R01 HL136725NHLBI NIH HHS R01 HL154549NHLBI NIH HHS R01 HL164612
6 · The paper itself

Abstract

backgroundAllergic asthma develops from allergen exposure in early childhood and progresses into adulthood. The central mediator of progressive allergic asthma is allergen-specific, T

objectivesThe aim of this study was to identify nerve-derived signals that act in T

methodsFollowing neonatal allergen exposure, allergen-specific T

resultsThis study found that sympathetic nerves produce dopamine and reside in proximity to T

conclusionsThese results demonstrate that maturing sympathetic nerves enable a dopamine-enriched lung environment in early life that promotes the establishment of allergen-specific T

Indexed as

AsthmaDopamineAdolescentAdultAllergensChildChild, PreschoolHumansInfant, NewbornInflammationLungTh1 CellsTh2 CellsYoung AdultAllergensDopamineAllergic asthmadopamineDRD4IL-2/IL2RAJARID2sympathetic nerveT(H)2-TRMs

Identifiers

PMID36841266
PMCPMC10440294
OpenAlexW4321793913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.