Evidence map›Paper›PMID 36840977›Full record

ArticleAdvanced materials (Deerfield Beach, Fla.)2023

2D Nano-Sonosensitizers Facilitate Energy Transfer to Enhance Sonodynamic Therapy.

Gan Lin, Geoffrey T Nash, Taokun Luo, Indranil Ghosh, Siddhartha Sohoni, Andrew J Christofferson, Gang Liu, Gregory S Engel, Wenbin Lin

Abstract read
In one paragraph

Article in Advanced materials (Deerfield Beach, Fla.), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Ultrasound-Activated BiOI/TiMaterials (Basel, Switzerland) · 2025
    Article
  6. Review
  7. Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Gan LinDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Geoffrey T NashDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Taokun LuoDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Indranil GhoshDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Siddhartha SohoniDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Andrew J ChristoffersonSchool of Science, College of Science, Engineering and Health, RMIT University, Melbourne, Victoria, 3001, Australia.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, 361102, China.
Gregory S EngelDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.
Wenbin LinDepartment of Chemistry, The University of Chicago, Chicago, IL, 60637, USA.ORCID https://orcid.org/0000-0001-7035-7759

Funding

VIRAL ONCOLOGY CORE FACILITYP30CA014599 · NCI · UNIVERSITY OF CHICAGO · PI CHIEN-MIN KAO · 1985 to 2026
$122.1M
Nanoscale Metal-Organic Frameworks Enable Radiotherapy-Radiodynamic Therapy and Deliver CpG Oligodeoxynucleotides to Generate Tumor Vaccines and Potentiate Immunotherapy of Head and Neck CancersR01CA253655 · NCI · UNIVERSITY OF CHICAGO · PI LIN, WENBIN, WEICHSELBAUM, RALPH R · 2020 to 2024
$2.5M
NCI NIH HHS 1R01CA253655NCI NIH HHS P30 CA014599NCI NIH HHS R01 CA253655
6 · The paper itself

Abstract

Although sonodynamic therapy (SDT) has shown promise for cancer treatment, the lack of efficient sonosensitizers (SSs) has limited the clinical application of SDT. Here, a new strategy is reported for designing efficient nano-sonosensitizers based on 2D nanoscale metal-organic layers (MOLs). Composed of Hf-oxo secondary building units (SBUs) and iridium-based linkers, the MOL is anchored with 5,10,15,20-tetra(p-benzoato)porphyrin (TBP) sensitizers on the SBUs to afford TBP@MOL. TBP@MOL shows 14.1- and 7.4-fold higher singlet oxygen (

Indexed as

NeoplasmsPorphyrinsUltrasonic TherapyAnimalsIridiumMiceOxygenSinglet OxygenIridiumOxygenPorphyrinsSinglet Oxygenenergy transfermetal-organic layersnanoparticlessonodynamic therapysonosensitizers

Identifiers

PMID36840977
PMCPMC10175216

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.