ArticleAngewandte Chemie (International ed. in English)2023
Practical and General Alcohol Deoxygenation Protocol.
Article in Angewandte Chemie (International ed. in English), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 77 citations in OpenAlex.
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- Electrochemically driven deoxychlorination of aliphatic alcoholsChemical science · 2026Article
- Interfacial Proton Ordering Near the Electrode Surface Directs Carbonyl Electroreduction to Methylene.Angewandte Chemie (International ed. in English) · 2026Article
- Benzodithiolane-Enabled C─O Bond Activation for Deoxygenative Functionalization of Carbohydrates and Nucleosides.Angewandte Chemie (International ed. in English) · 2026Article
- Illuminating Synergistic Catalysis: SET-HAT Unlocks Proximal C-H Arylation of Aromatic Amines.JACS Au · 2026Article
- Harnessing COJournal of the American Chemical Society · 2026Article
- Reductive radical chain initiation through the thermal generation of carbon dioxide radical anion.Nature synthesis · 2026Article
- Synthesis of depressin, cryptomeridiol and 4-Beilstein journal of organic chemistry · 2026Article
- Electrochemical Deoxygenative Silylation of Alcohols.Angewandte Chemie (International ed. in English) · 2025Article
- Deoxygenative Functionalization of Alcohols and Carbonyl Compounds via Electrochemical Reduction.Angewandte Chemie (International ed. in English) · 2025Article
- Photocatalytic deoxygenative Z-selective olefination of aliphatic alcohols.Nature communications · 2025Article
- Visible-Light-Driven Carboxylative 1,2-Difunctionalization of C=C Bonds with Tetrabutylammonium Oxalate.ACS central science · 2025Article
- Selective C-N Bond Cleavage in Unstrained Pyrrolidines Enabled by Lewis Acid and Photoredox Catalysis.Journal of the American Chemical Society · 2024Article
- 1,4-Dihydropyridine Anions as Potent Single-Electron Photoreductants.Organic letters · 2024Article
- Single electron reduction of NHC-COChemical science · 2024Article
- Rational design of super reductive EDA photocatalyst for challenging reactions: a theoretical and experimental study.RSC advances · 2024Article
- SOMOphilic alkyne vs radical-polar crossover approaches: The full story of the azido-alkynylation of alkenes.Beilstein journal of organic chemistry · 2024Article
- Mechanisms for radical reactions initiating fromBeilstein journal of organic chemistry · 2024Article
- Recent Advances in C-H Functionalisation through Indirect Hydrogen Atom Transfer.Molecules (Basel, Switzerland) · 2023Review
- Electrochemically Driven Deoxygenative Borylation of Alcohols and Carbonyl Compounds.Journal of the American Chemical Society · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Herein, we describe a practical protocol for the removal of alcohol functional groups through reductive cleavage of their benzoate ester analogs. This transformation requires a strong single electron transfer (SET) reductant and a means to accelerate slow fragmentation following substrate reduction. To accomplish this, we developed a photocatalytic system that generates a potent reductant from formate salts alongside Brønsted or Lewis acids that promote fragmentation of the reduced intermediate. This deoxygenation procedure is effective across structurally and electronically diverse alcohols and enables a variety of difficult net transformations. This protocol requires no precautions to exclude air or moisture and remains efficient on multigram scale. Finally, the system can be adapted to a one-pot benzoylation-deoxygenation sequence to enable direct alcohol deletion. Mechanistic studies validate that the role of acidic additives is to promote the key C(sp
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.