Evidence map›Paper›PMID 36840837›Full record

ReviewHuman cell2023

The role of non-coding RNA in lupus nephritis.

Hanzhi Liang, Qinghua Liu

Abstract readReview
PubMed Publisher
In one paragraph

Review in Human cell, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
2.9field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Hanzhi LiangDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Second Road, Yuexiu District, Guangdong Province, China.
Qinghua LiuDepartment of Nephrology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Second Road, Yuexiu District, Guangdong Province, China. liuqhua6@mail.sysu.edu.cn.ORCID http://orcid.org/0000-0002-6385-5482
Sun Yat-sen University · CN

Funding

National Natural Science Foundation of China 81370863
6 · The paper itself

Abstract

Systemic lupus erythematosus (SLE) is a common autoimmune disease with multiple manifestations. The renal implication, also called lupus nephritis (LN) is the most regular type of complication and results in adverse outcomes. Multiple studies revealed the importance of non-coding RNA in diseases, likewise observed in nephropathies, particularly LN. Long-non-coding RNA (lncRNA) is a group of RNA that are more than 200 nucleotides in length. And in circular RNA (circRNA), the head and tail of RNA are connected by a 3' → 5' phosphodiester bond. Both two types of non-coding RNA play important roles in LN pathogenesis through the competitive endogenous RNA (ceRNA) effect. LncRNAs and circRNAs can sponge miRNAs and consequently act on downstream signaling pathways, which are capable to influence various aspects of LN, including cell proliferation, inflammation, and oxidative stress. And lncRNAs and circRNAs have the potential to act as biomarkers to diagnose LN and distinguish whether SLE patients with LN or not. In the future, lncRNAs and circRNAs may be accessible therapeutic targets.

Indexed as

Lupus Erythematosus, SystemicLupus NephritisMicroRNAsRNA, Long NoncodingBiomarkersHumansRNA, CircularBiomarkersMicroRNAsRNA, CircularRNA, Long NoncodingBiomarkerCircular RNALong-non-coding RNALupus nephritis

Identifiers

PMID36840837
OpenAlexW4321851654

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.