Evidence map›Paper›PMID 36840717›Full record

ArticleNucleic acids research2023

Linker histone H1 modulates defense priming and immunity in plants.

Arsheed H Sheikh, Kashif Nawaz, Naheed Tabassum, Marilia Almeida-Trapp, Kiruthiga G Mariappan, Hanna Alhoraibi, Naganand Rayapuram, Manuel Aranda, Martin Groth, Heribert Hirt

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nucleic acids research, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
11.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Arsheed H SheikhKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0003-1883-5439
Kashif NawazKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0002-5482-3366
Naheed TabassumKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0003-2073-3132
Marilia Almeida-TrappKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0002-9980-322X
Kiruthiga G MariappanKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0002-0831-8756
Hanna AlhoraibiDepartment of Biochemistry, Faculty of Science, King Abdulaziz University, 21551Jeddah, Saudi Arabia.
Naganand RayapuramKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0003-2056-3735
Manuel ArandaKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0001-6673-016X
Martin GrothInstitute of Functional Epigenetics, Helmholtz Munich, 85764Neuherberg, Germany.ORCID 0000-0003-0547-5032
Heribert HirtKing Abdullah University of Science and Technology, KAUST, 23955 Thuwal, Saudi Arabia.ORCID 0000-0003-3119-9633
King Abdullah University of Science and Technology · SAHelmholtz Zentrum München · DEKing Abdulaziz University · SA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Linker H1 histones play an important role in animal and human pathogenesis, but their function in plant immunity is poorly understood. Here, we analyzed mutants of the three canonical variants of Arabidopsis H1 histones, namely H1.1, H1.2 and H1.3. We observed that double h1.1h1.2 and triple h1.1h1.2h1.3 (3h1) mutants were resistant to Pseudomonas syringae and Botrytis cinerea infections. Transcriptome analysis of 3h1 mutant plants showed H1s play a key role in regulating the expression of early and late defense genes upon pathogen challenge. Moreover, 3h1 mutant plants showed enhanced production of reactive oxygen species and activation of mitogen activated protein kinases upon pathogen-associated molecular pattern (PAMP) treatment. However, 3h1 mutant plants were insensitive to priming with flg22, a well-known bacterial PAMP which induces enhanced resistance in WT plants. The defective defense response in 3h1 upon priming was correlated with altered DNA methylation and reduced global H3K56ac levels. Our data place H1 as a molecular gatekeeper in governing dynamic changes in the chromatin landscape of defense genes during plant pathogen interaction.

Indexed as

ArabidopsisArabidopsis ProteinsHistonesHost-Pathogen InteractionsPlant DiseasesPlant ImmunityBacterial ProteinsBotrytisChromatinDNA MethylationGene Expression Regulation, PlantHMGA ProteinsMitogen-Activated Protein KinasesMutationPathogen-Associated Molecular Pattern MoleculesPseudomonas syringaeArabidopsis ProteinsBacterial ProteinsChromatinHistonesHMGA ProteinsHON4 protein, ArabidopsisMitogen-Activated Protein KinasesPathogen-Associated Molecular Pattern MoleculesReactive Oxygen Species

Identifiers

PMID36840717
PMCPMC10201415
OpenAlexW4321997000

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.