Evidence map›Paper›PMID 36840642›Full record

ArticleRheumatology (Oxford, England)2023

Measuring the impact of steroid therapy on health-related quality of life in patients with rheumatic diseases: international development of a glucocorticoid treatment-specific patient-reported outcome measure.

Susan Bridgewater, Michael A Shepherd, Jill Dawson, Pamela Richards, Christine Silverthorne, Mwidimi Ndosi, Celia Almeida, Rachel J Black, Jonathan T L Cheah, Emma Dures and 12 more

Registry-linked trialOpen access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Rheumatology (Oxford, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06314451 (Cross-condition Validation of the Patient Reported Outcome Measure for Patients Receiving Glucocorticoids), which is not on this map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06314451 unknown statusnot on this map

Cross-condition Validation of the Patient Reported Outcome Measure for Patients Receiving Glucocorticoids (the Steroid PRO)

TypeobservationalSponsorUniversity of the West of EnglandRan2022 to 2024Enrolled60ConditionsInflammatory Disease, Immune System Disorder, Gastrointestinal Diseases, Dermatologic DiseaseArmsCognitive Interview
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 5 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 10 institutions in 3 countries.

Susan BridgewaterFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.ORCID 0000-0002-3669-8426
Michael A ShepherdFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.ORCID 0000-0002-1791-8016
Jill DawsonDepartment of Population Health (HSRU), University of Oxford, Oxford, UK.ORCID 0000-0002-2358-1333
Pamela RichardsAcademic Rheumatology Department, University Hospitals Bristol and Weston NHS Foundation Trust, Bristol, UK.
Christine SilverthorneFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.ORCID 0000-0001-8145-2305
Mwidimi NdosiFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.ORCID 0000-0002-7764-3173
Celia AlmeidaFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.
Rachel J BlackDiscipline of Medicine, The University of Adelaide, Adelaide, Australia.ORCID 0000-0001-6600-7430
Jonathan T L CheahDepartment of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0003-1828-7284
Emma DuresFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.ORCID 0000-0002-6674-8607
Nilasha GhoshDivision of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-8799-9309
Elizabeth A HoonDiscipline of General Practice, The University of Adelaide, Adelaide, Australia.
Suellen LyneDiscipline of Medicine, The University of Adelaide, Adelaide, Australia.ORCID 0000-0002-9601-142X
Iris Navarro-MillanDepartment of Medicine, Division of Rheumatology, University of Massachusetts Medical School, Worcester, MA, USA.ORCID 0000-0002-9540-6614
Diyu Pearce-FisherDivision of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0002-2462-6644
Carlee RuedigerDepartment of Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia.
Joanna TieuDepartment of Rheumatology, The Queen Elizabeth Hospital, Adelaide, Australia.ORCID 0000-0002-2975-176X
Kevin YipDivision of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-4011-6238
Sarah L MackieLeeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, Leeds, UK.ORCID 0000-0003-2483-5873
Susan GoodmanDivision of Rheumatology, Hospital for Special Surgery, Weill Cornell Medicine, New York, NY, USA.ORCID 0000-0003-1197-7864
Catherine HillDiscipline of Medicine, The University of Adelaide, Adelaide, Australia.ORCID 0000-0001-8289-4922
Joanna C RobsonFaculty of Health and Applied Sciences, School of Health and Social Wellbeing, University of the West of England-UWE Bristol, Bristol, UK.ORCID 0000-0002-7939-5978
University of the West of England · GBHospital for Special Surgery · USQueen Elizabeth Hospital · AURoyal Adelaide Hospital · AUUniversity of Massachusetts Chan Medical School · USLyell McEwin Hospital · AUThe University of Adelaide · AUUniversity Hospitals Bristol NHS Foundation Trust · GBUniversity of Leeds · GBUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesGlucocorticoids (GCs) ('steroids') are used to treat rheumatic diseases but adverse effects are common. We aimed to explore the impact of GC therapy on health-related quality of life (HRQoL), to inform the development of a treatment-specific patient-reported outcome measure (PROM) for use in clinical trials and practice.

methodsSemi-structured qualitative interviews were conducted with patients from the UK, USA and Australia, treated for a rheumatic condition with GCs in the last 2 years. Purposive sampling was used to select participants with a range of demographic and disease features. An initial conceptual framework informed interview prompts and cues. Interviews elicited GC-related physical and psychological symptoms and salient aspects of HRQoL in relation to GC therapy. Interview data were analysed inductively to develop initial individual themes and domains. Candidate questionnaire items were developed and refined.

resultsSixty semi-structured qualitative interviews were conducted (UK n = 34, USA n = 10, Australia n = 16). The mean age was 58 years; 39/60 were female; and 18 rheumatic diseases were represented. Some 126 individual themes were identified and organized into six domains: physical symptoms; psychological symptoms; psychological impact of steroids; impact of steroids on participation; impact of steroids on relationships; and benefits of steroids. Candidate questionnaire items were tested and refined by piloting with patient research partners, iterative rounds of cognitive interviews and linguistic translatability assessment, informing a draft questionnaire.

conclusionWe describe an international qualitative study to develop candidate items for a treatment-specific PROM for patients with rheumatic diseases. A future survey will enable the validation of a final version of the PROM.

Indexed as

Quality of LifeRheumatic DiseasesFemaleGlucocorticoidsHumansMaleMiddle AgedPatient Reported Outcome MeasuresSteroidsSurveys and QuestionnairesGlucocorticoidsSteroidsglucocorticoid steroidspatient-reported outcomesquality of liferheumatic diseases

Identifiers

PMID36840642
PMCPMC10629780
OpenAlexW4321851555

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.