Evidence map›Paper›PMID 36840605›Full record

Observational studyMultiple sclerosis (Houndmills, Basingstoke, England)2023

Acute central nervous system inflammation following COVID-19 vaccination: An observational cohort study.

Sydney Lee, Alexandra Muccilli, Raphael Schneider, Daniel Selchen, Kristen M Krysko

Abstract readObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Multiple sclerosis (Houndmills, Basingstoke, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Review
  3. Early-onset Cervical Myelitis after COVID-19 Vaccination.Internal medicine (Tokyo, Japan) · 2023
    Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sydney LeeDepartment of Medicine, University of Toronto, St. Michael's Hospital, Toronto, ON, Canada.ORCID 0000-0002-8591-2062
Alexandra MuccilliDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Raphael SchneiderDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada Li Ka Shing Knowledge Institute, Toronto, ON, Canada.
Daniel SelchenDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada.
Kristen M KryskoDivision of Neurology, Department of Medicine, BARLO MS Centre, St. Michael's Hospital, University of Toronto, Toronto, ON, Canada Li Ka Shing Knowledge Institute, Toronto, ON, Canada.ORCID 0000-0003-0090-597X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundReports suggest a potential association between coronavirus disease 2019 (COVID-19) vaccines and acute central nervous system (CNS) inflammation.

objectiveThe main objective of this study is to describe features of acute CNS inflammation following COVID-19 vaccination.

methodsA retrospective observational cohort study was performed at the BARLO MS Centre in Toronto, Canada. Clinicians reported acute CNS inflammatory events within 60 days after a COVID-19 vaccine from March 2021 to August 2022. Clinical characteristics were evaluated.

resultsThirty-eight patients (median age 39 (range: 20-82) years; 60.5% female) presented within 0-55 (median 15) days of a receiving a COVID-19 vaccine and were diagnosed with relapsing remitting multiple sclerosis (MS) (

conclusionTo our knowledge, this is the largest study describing acute CNS inflammation after COVID-19 vaccination. We could not determine whether the number of inflammatory events was higher than expected.

Indexed as

COVID-19Neuromyelitis OpticaCentral Nervous SystemCohort StudiesCOVID-19 VaccinesFemaleHumansInflammationMaleMyelin-Oligodendrocyte GlycoproteinNeoplasm Recurrence, LocalRetrospective StudiesVaccinationCOVID-19 VaccinesMyelin-Oligodendrocyte Glycoproteincentral nervous systemCOVID-19demyelinating diseasesmultiple sclerosisneuroinflammatory diseasesvaccination

Identifiers

PMID36840605
PMCPMC9969223

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.