Evidence map›Paper›PMID 36840604›Full record

ArticleJournal of clinical microbiology2023

Machine-Learning Model for Prediction of Cefepime Susceptibility in Escherichia coli from Whole-Genome Sequencing Data.

Romney M Humphries, Eugene Bragin, Julian Parkhill, Grace Morales, Jonathan E Schmitz, Paul A Rhodes

Open access · greenAbstract read
In one paragraph

Article in Journal of clinical microbiology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 2 pooled it
4.6field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 2 syntheses or guidelines pooled it, 24 citations in OpenAlex.

  1. Pooled it
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  9. Advancements in AI-driven drug sensitivity testing research.Frontiers in cellular and infection microbiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Romney M HumphriesVanderbilt University Medical Center, Nashville, Tennesee, USA.ORCID 0000-0002-6568-156X
Eugene BraginNext Gen Diagnostics, LLC, Cambridge, United Kingdom.
Julian ParkhillDepartment of Veterinary Medicine, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-7069-5958
Grace MoralesVanderbilt University Medical Center, Nashville, Tennesee, USA.
Jonathan E SchmitzVanderbilt University Medical Center, Nashville, Tennesee, USA.ORCID 0000-0002-2727-9078
Paul A RhodesNext Gen Diagnostics, LLC, Cambridge, United Kingdom.
Vanderbilt University Medical Center · USQuest Diagnostics (United Kingdom) · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The declining cost of performing bacterial whole-genome sequencing (WGS) coupled with the availability of large libraries of sequence data for well-characterized isolates have enabled the application of machine-learning (ML) methods to the development of nonlinear sequence-based predictive models. We tested the ML-based model developed by Next Gen Diagnostics for prediction of cefepime phenotypic susceptibility results in Escherichia coli. A cohort of 100 isolates of E. coli recovered from urine (

Indexed as

Anti-Bacterial AgentsEscherichia coliCefepimeCephalosporinsHumansMicrobial Sensitivity TestsAnti-Bacterial AgentsCefepimeCephalosporinsASTcefepimemachine learningMICwhole-genome sequencing

Identifiers

PMID36840604
PMCPMC10035297
OpenAlexW4321493185

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.