Evidence map›Paper›PMID 36840588›Full record

ArticleAntimicrobial agents and chemotherapy2023

Killing Two Birds with One Stone: Discovery of Dual Inhibitors of Oxygen and Fumarate Respiration in Zoonotic Parasite, Echinococcus multilocularis.

Shigehiro Enkai, Hirokazu Kouguchi, Daniel Ken Inaoka, Tomoo Shiba, Masahito Hidaka, Hiroyuki Matsuyama, Takaya Sakura, Kinpei Yagi, Kiyoshi Kita

Open access · hybridFull text read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Resveratrol againstTropical medicine and infectious disease · 2023
    Article
  5. Fumarate respiration ofFrontiers in cellular and infection microbiology · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Shigehiro EnkaiDepartment of Pediatrics, Teikyo University School of Medicine, Tokyo, Japan.ORCID 0000-0001-6729-9789
Hirokazu KouguchiDepartment of Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan.
Daniel Ken InaokaSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.ORCID 0000-0002-9791-927X
Tomoo ShibaDepartment of Applied Biology, Graduate School of Science Technology, Kyoto Institute of Technology, Kyoto, Japan.
Masahito HidakaDepartment of Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan.
Hiroyuki MatsuyamaDepartment of Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan.
Takaya SakuraSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Kinpei YagiDepartment of Infectious Diseases, Hokkaido Institute of Public Health, Sapporo, Hokkaido, Japan.
Kiyoshi KitaSchool of Tropical Medicine and Global Health, Nagasaki University, Nagasaki, Japan.
Nagasaki University · JPHokkaido Institute of Public Health · JPHokkaido University · JPKyoto Institute of Technology · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ascofuranone (AF), a meroterpenoid isolated from various filamentous fungi, including

Indexed as

Echinococcus multilocularisParasitesAnimalsFumaratesNADRespirationFumaratesNADascofuranonedrug developmentdual inhibitorsEchinococcus multilocularisfumarate respirationmitochondrial complex IIstructure-activity relationship

Identifiers

PMID36840588
PMCPMC10019194
OpenAlexW4321493241

What OpenQuestion holds

Textfull text, public
LicenceCC BY
measurements read20
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.