Evidence map›Paper›PMID 36840036›Full record

ArticlePharmaceutics2023

Development of 3D Printed Multi-Layered Orodispersible Films with Porous Structure Applicable as a Substrate for Inkjet Printing.

Jan Elbl, Martin Veselý, Dagmar Blaháčková, Jaroslav Ondruš, Pavel Kulich, Eliška Mašková, Josef Mašek, Jan Gajdziok

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Jan ElblDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University Brno, Palackého tř. 1946/1, 612 42 Brno, Czech Republic.ORCID 0000-0001-5053-5669
Martin VeselýDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University Brno, Palackého tř. 1946/1, 612 42 Brno, Czech Republic.ORCID 0000-0002-0352-8084
Dagmar BlaháčkováDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University Brno, Palackého tř. 1946/1, 612 42 Brno, Czech Republic.
Jaroslav OndrušDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.ORCID 0000-0001-6502-6840
Pavel KulichDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Eliška MaškováDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.ORCID 0000-0002-0838-7401
Josef MašekDepartment of Pharmacology and Toxicology, Veterinary Research Institute, Hudcova 70, 621 00 Brno, Czech Republic.
Jan GajdziokDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Masaryk University Brno, Palackého tř. 1946/1, 612 42 Brno, Czech Republic.ORCID 0000-0001-5599-5648
Masaryk University · CZVeterinary Research Institute · CZ

Funding

Masaryk University MUNI/A/1151/2021
6 · The paper itself

Abstract

The direct tailoring of the size, composition, or number of layers belongs to the advantages of 3D printing employment in producing orodispersible films (ODFs) compared to the frequently utilized solvent casting method. This study aimed to produce porous ODFs as a substrate for medicated ink deposited by a 2D printer. The innovative semi-solid extrusion 3D printing method was employed to produce multilayered ODFs, where the bottom layer assures the mechanical properties. In contrast, the top layer provides a porous structure for ink entrapment. Hydroxypropyl methylcellulose and polyvinyl alcohol were utilized as film-forming polymers, glycerol as a plasticizer, and sodium starch glycolate as a disintegrant in the bottom matrix. Several porogen agents (Aeroperl

Indexed as

3D printfast dissolving filmsindividualized therapyinkjet printoral filmsporous films

Identifiers

PMID36840036
PMCPMC9961792
OpenAlexW4321459949

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.