Evidence map›Paper›PMID 36839949›Full record

ArticlePharmaceutics2023

A Gelatin Methacrylate-Based Hydrogel as a Potential Bioink for 3D Bioprinting and Neuronal Differentiation.

Elisa Marozzi Cruz, Lucas Simões Machado, Laura Nicoleti Zamproni, Larissa Valdemarin Bim, Paula Scanavez Ferreira, Leonardo Alves Pinto, Luiz Antonio Pessan, Eduardo Henrique Backes, Marimélia Aparecida Porcionatto

Abstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Elisa Marozzi CruzDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Lucas Simões MachadoDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0003-2946-1129
Laura Nicoleti ZamproniDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0003-2219-6676
Larissa Valdemarin BimDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0001-6635-5216
Paula Scanavez FerreiraDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.
Leonardo Alves PintoDepartment of Materials Engineering, Universidade Federal de São Carlos, São Carlos 13565-905, Brazil.
Luiz Antonio PessanDepartment of Materials Engineering, Universidade Federal de São Carlos, São Carlos 13565-905, Brazil.
Eduardo Henrique BackesDepartment of Materials Engineering, Universidade Federal de São Carlos, São Carlos 13565-905, Brazil.ORCID 0000-0003-2604-686X
Marimélia Aparecida PorcionattoDepartment of Biochemistry, Escola Paulista de Medicina, Universidade Federal de São Paulo, São Paulo 04039-032, Brazil.ORCID 0000-0001-6287-916X

Funding

Coordenação de Aperfeicoamento de Pessoal de Nível Superior financial code 001National Council for Scientific and Technological Development 465656/2014-5 and 309679/2018-4 (MAP);São Paulo Research Foundation 2018/12605-8 (MAP), 2019/27415-2 (LAP), 2020/11374-2 (EHB), 2021/14327-8 (LNZ), 2020/12454-0 (EMC);
6 · The paper itself

Abstract

Neuronal loss is the ultimate pathophysiologic event in central nervous system (CNS) diseases and replacing these neurons is one of the most significant challenges in regenerative medicine. Providing a suitable microenvironment for new neuron engraftment, proliferation, and synapse formation is a primary goal for 3D bioprinting. Among the various biomaterials, gelatin methacrylate (GelMA) stands out due to its Arg-Gly-Asp (RGD) domains, which assure its biocompatibility and degradation under physiological conditions. This work aimed to produce different GelMA-based bioink compositions, verify their mechanical and biological properties, and evaluate their ability to support neurogenesis. We evaluated four different GelMA-based bioink compositions; however, when it came to their biological properties, incorporating extracellular matrix components, such as Geltrex

Indexed as

astrocyte de-differentiationbioprintingGelMAneurogenesisneuroprogenitor cells

Identifiers

PMID36839949
PMCPMC9959598

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.