Evidence map›Paper›PMID 36839918›Full record

ArticlePharmaceutics2023

Lipopolyplex-Mediated Co-Delivery of Doxorubicin and FAK siRNA to Enhance Therapeutic Efficiency of Treating Colorectal Cancer.

Tilahun Ayane Debele, Chi-Kang Chen, Lu-Yi Yu, Chun-Liang Lo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tilahun Ayane DebeleDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.ORCID 0000-0002-1039-9620
Chi-Kang ChenDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Lu-Yi YuDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Chun-Liang LoDepartment of Biomedical Engineering, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.

Funding

National Science and Technology Council, Taiwan 111-2221-E-A49-005-MY3, 111-2314-B-A49-050-MY3 and 111-2811-B-A49A-041
6 · The paper itself

Abstract

Tumor metastasis is a major concern in cancer therapy. In this context, focal adhesion kinase (FAK) gene overexpression, which mediates cancer cell migration and invasion, has been reported in several human tumors and is considered a potential therapeutic target. However, gene-based treatment has certain limitations, including a lack of stability and low transfection ability. In this study, a biocompatible lipopolyplex was synthesized to overcome the aforementioned limitations. First, polyplexes were prepared using poly(2-Hydroxypropyl methacrylamide-

Indexed as

cancer therapychemotherapygene therapylipopolyplexpolyplexpyridoxal

Identifiers

PMID36839918
PMCPMC9968081

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.