Evidence map›Paper›PMID 36839866›Full record

ArticlePharmaceutics2023

Development of Autopolymerizing Resin Material with Antimicrobial Properties Using Montmorillonite and Nanoporous Silica.

Shuhei Otsubo, Ko Nakanishi, Kakufu Fukukawa, Ryoshun Endo, Seiichiro Yoshida, Aiko Matsumoto, Kumiko Yoshihara, Tsukasa Akasaka, Akira Hasebe, Yasuhiro Yoshida and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Shuhei OtsuboDepartment of Orthodontics, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.ORCID 0000-0003-4400-0718
Ko NakanishiDepartment of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Kakufu FukukawaDepartment of Oral Functional Prosthodontics, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Ryoshun EndoDepartment of Orthodontics, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Seiichiro YoshidaIndustrial Research Institute, Industrial Technology and Environment Research Department, Hokkaido Research Organization, Sapporo 060-0819, Japan.
Aiko MatsumotoDepartment of Orthodontics, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Kumiko YoshiharaNational Institute of Advanced Industrial Science and Technology (AIST), Health and Medical Research Institute, Takamatsu 761-0395, Japan.ORCID 0000-0002-3483-6012
Tsukasa AkasakaDepartment of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Akira HasebeDepartment of Oral Molecular Microbiology, Faculty of Dental Medicine and Graduate School of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Yasuhiro YoshidaDepartment of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Yoshiaki SatoDepartment of Orthodontics, Faculty of Dental Medicine, Hokkaido University, Kita13, Nishi7, Kita-ku, Sapporo 060-8586, Japan.
Hokkaido University · JPHokkaido Research Organization · JPNational Institute of Advanced Industrial Science and Technology · JP

Funding

JSPS KAKENHI 19K19281JSPS KAKENHI 22K17222
6 · The paper itself

Abstract

Although autopolymerizing resin offers numerous applications in orthodontic treatment, plaque tends to accumulate between the appliance and the mucosa, which increases the number of microorganisms present. In this study, we added cetylpyridinium chloride (CPC) loaded montmorillonite (Mont) and nanoporous silica (NPS) to autopolymerizing resin (resin-Mont, resin-NPS) and evaluated their drug release capacity, antimicrobial capacity, drug reuptake capacity, mechanical strength, and color tone for the devolvement of autopolymerizing resin with antimicrobial properties. As observed, resin-Mont and resin-NPS were capable of the sustained release of CPC for 14 d, and a higher amount of CPC was released compared to that of resin-CPC. Additionally, resin-Mont and resin-NPS could reuptake CPC. Moreover, the antimicrobial studies demonstrated that resin-Mont and resin-NPS could release effective amounts of CPC against

Indexed as

antimicrobialAutopolymerizing Resin Materialcetylpyridinium chloridedrug releasemontmorillonitenanoporous silicaorthodontic treatment

Identifiers

PMID36839866
PMCPMC9962014
OpenAlexW4319441488

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.