Evidence map›Paper›PMID 36839800›Full record

ArticlePharmaceutics2023

Parasitological, Molecular, and Histopathological Investigation of the Potential Activity of Propolis and Wheat Germ Oil against Acute Toxoplasmosis in Mice.

Ashraf Mohamed Barakat, Khaled A Abd El-Razik, Hassan Ali Mohamed El Fadaly, Walaa M Saleh, Fatma Abo Zakaib Ali, Asmaa Aboelabbas Gouda, Sabry A S Sadek, Naief Dahran, Manal F El-Khadragy, Ehab Kotb Elmahallawy

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.4field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
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  8. Potent In Vitro and In Vivo Effects ofTropical medicine and infectious disease · 2023
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Ashraf Mohamed BarakatDepartment of Zoonotic Diseases, National Research Centre, El Buhouth St., Dokki, Giza 12622, Egypt.
Khaled A Abd El-RazikDepartment of Animal Reproduction, Veterinary Research Institute, National Research Centre, Giza 12556, Egypt.ORCID 0000-0002-8895-2895
Hassan Ali Mohamed El FadalyDepartment of Zoonotic Diseases, National Research Centre, El Buhouth St., Dokki, Giza 12622, Egypt.
Walaa M SalehDepartment of Parasitology, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.
Fatma Abo Zakaib AliDepartment of Pathology and Clinical Pathology, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.ORCID 0000-0001-6415-0647
Asmaa Aboelabbas GoudaDepartment of Parasitology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Egypt.
Sabry A S SadekDepartment of Zoonotic Diseases, National Research Centre, El Buhouth St., Dokki, Giza 12622, Egypt.
Naief DahranDepartment of Anatomy, Faculty of Medicine, University of Jeddah, Jeddah 21959, Saudi Arabia.ORCID 0000-0003-3560-8166
Manal F El-KhadragyDepartment of Biology, College of Science, Princess Nourah bint Abdulrahman University, P.O. Box 84428, Riyadh 11671, Saudi Arabia.
Ehab Kotb ElmahallawyDepartment of Zoonoses, Faculty of Veterinary Medicine, Sohag University, Sohag 82524, Egypt.ORCID 0000-0003-4484-3678
National Research Centre · EGSohag University · EGPrincess Nourah bint Abdulrahman University · SAUniversity of Jeddah · SAZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Toxoplasmosis is one of the most common parasitic zoonoses that affects all vertebrates. The drugs most commonly used against toxoplasmosis have many side effects, making the development of new antiparasitic drugs a big challenge. The present study evaluated the therapeutic effectiveness of novel herbal treatments, including propolis and wheat germ oil (WGO), against acute toxoplasmosis. A total of 50 albino mice were divided into five groups: group 1 (G1) (non-infected and non-treated); group 2 (G2) (infected without treatment); group 3 (G3) (treated with propolis); group 4 (G4) (treated with WGO); group 5 (G5) (treated with a combination of propolis and WGO). The effects of the herbal substances on different organs, mainly liver, spleen, and lungs, were investigated using parasitological, molecular, and histopathological examinations. The results of parasitological examination demonstrated statistically significant (

Indexed as

liverlungsparasite burdenparasite loadpropolistissue cysttoxoplasmosiswheat germ

Identifiers

PMID36839800
PMCPMC9967381
OpenAlexW4318777848

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.