ArticlePharmaceutics2023
Evaluation of a Medical Grade Thermoplastic Polyurethane for the Manufacture of an Implantable Medical Device: The Impact of FDM 3D-Printing and Gamma Sterilization.
Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 36 citations in OpenAlex.
- HME-FDM 3D-Printed Implantable Drug Delivery Systems-From Design to Characterization.Pharmaceutics · 2026Review
- A Comparison of Ester- and Ether-Based Bio-TPUs With Regard to Their Resistance to Environmental Influences in Terms of Their Mechanical and Adhesive Properties.Biopolymers · 2025Article
- In Vitro Degradation Studies of 3D-Printed Thermoplastic Polyurethane for the Design of Vascular Implant.Materials (Basel, Switzerland) · 2025Article
- Multi-objective optimization of surface finish and VOC emissions in FFF 3D printing using ANN-NSGA-II approach.Scientific reports · 2025Article
- Stabilization of Self-Pressurized Gelatin Capsules for Oral Delivery of Biologics.Pharmaceutics · 2025Article
- Innovative spiral nerve conduits: Addressing nutrient transport and cellular activity for critical-sized nerve defects.Bioactive materials · 2025Article
- Article
- Cerium Oxide and Chondroitin Sulfate Doped Polyurethane Scaffold to Bridge Tendons.ACS applied materials & interfaces · 2023Article
- Implementation of 3D Printing and Modeling Technologies for the Fabrication of Dose Boluses for External Radiotherapy at the CLCC of Sétif, Algeria.Technology in cancer research & treatmentArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Three-dimensional printing (3DP) of thermoplastic polyurethane (TPU) is gaining interest in the medical industry thanks to the combination of tunable properties that TPU exhibits and the possibilities that 3DP processes offer concerning precision, time, and cost of fabrication. We investigated the implementation of a medical grade TPU by fused deposition modelling (FDM) for the manufacturing of an implantable medical device from the raw pellets to the gamma (γ) sterilized 3DP constructs. To the authors' knowledge, there is no such guide/study implicating TPU, FDM 3D-printing and gamma sterilization. Thermal properties analyzed by differential scanning calorimetry (DSC) and molecular weights measured by size exclusion chromatography (SEC) were used as monitoring indicators through the fabrication process. After gamma sterilization, surface chemistry was assessed by water contact angle (WCA) measurement and infrared spectroscopy (ATR-FTIR). Mechanical properties were investigated by tensile testing. Biocompatibility was assessed by means of cytotoxicity (ISO 10993-5) and hemocompatibility assays (ISO 10993-4). Results showed that TPU underwent degradation through the fabrication process as both the number-averaged (Mn) and weight-averaged (Mw) molecular weights decreased (7% Mn loss, 30% Mw loss,
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.