Evidence map›Paper›PMID 36839775›Full record

ArticlePharmaceutics2023

Biological Evaluation and In Vitro Characterization of ADME Profile of In-House Pyrazolo[3,4-

Federica Poggialini, Chiara Vagaggini, Annalaura Brai, Claudia Pasqualini, Emmanuele Crespan, Giovanni Maga, Cecilia Perini, Noemi Cabella, Lorenzo Botta, Francesca Musumeci and 3 more

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.2field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Small Molecule Tyrosine Kinase Inhibitors (TKIs) for Glioblastoma Treatment.International journal of molecular sciences · 2024
    Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Federica PoggialiniDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.ORCID 0000-0002-8225-4631
Chiara VagagginiDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4208-7760
Annalaura BraiDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.ORCID 0000-0001-6395-9348
Claudia PasqualiniDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.ORCID 0000-0002-9120-1689
Emmanuele CrespanInstitute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.
Giovanni MagaInstitute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.ORCID 0000-0001-8092-1552
Cecilia PeriniInstitute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.ORCID 0000-0003-0270-3781
Noemi CabellaInstitute of Molecular Genetics (IGM), CNR "Luigi Luca Cavalli-Sforza", 27100 Pavia, Italy.
Lorenzo BottaDepartment of Ecological and Biological Sciences, University of Tuscia, Via S.C. De Lellis s.n.c., 01100 Viterbo, Italy.ORCID 0000-0002-0856-2986
Francesca MusumeciDepartment of Pharmacy, University of Genoa, 16132 Genoa, Italy.ORCID 0000-0002-7228-0086
Maria FrosiniDepartment of Life Sciences, University of Siena, 53100 Siena, Italy.ORCID 0000-0002-4452-8128
Silvia SchenoneDepartment of Pharmacy, University of Genoa, 16132 Genoa, Italy.
Elena DreassiDepartment of Biotechnology, Chemistry and Pharmacy (DBCF), University of Siena, 53100 Siena, Italy.ORCID 0000-0001-8987-940X
University of Siena · ITIstituto di Genetica Molecolare · ITUniversity of Genoa · ITUniversità degli Studi della Tuscia · IT

Funding

Italian Association for Cancer Research IG-2017 20762Italian Association for Cancer Research IG-2019 23725Italian Association for Cancer Research IG-2020 24448Ministry of Education, Universities and Research PRIN 2017 2017SA5837_004Tuscany Region TUSCAVIR.NET Bando Ricerca Salute 2018 B64I18013740002
6 · The paper itself

Abstract

The therapeutic use of tyrosine kinase inhibitors (TKIs) represents one of the successful strategies for the treatment of glioblastoma (GBM). Pyrazolo[3,4-

Indexed as

ADMEantiproliferative activityc-Src/Abl dual inhibitorsglioblastomapyrazolo[3,4-d]pyrimidinestyrosine kinase

Identifiers

PMID36839775
PMCPMC9966370
OpenAlexW4318480254

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.