Evidence map›Paper›PMID 36839746›Full record

ReviewPharmaceutics2023

Development of Janus Particles as Potential Drug Delivery Systems for Diabetes Treatment and Antimicrobial Applications.

Kei Xian Tan, Michael K Danquah, Jaison Jeevanandam, Ahmed Barhoum

Open access · goldAbstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 39 citations in OpenAlex.

  1. Review
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  7. Preparation of Asymmetric AlMaterials (Basel, Switzerland) · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 4 countries.

Kei Xian TanGenScript Biotech Pte. Ltd., 164, Kallang Way, Solaris@Kallang 164, Singapore 349248, Singapore.ORCID 0000-0001-6947-8377
Michael K DanquahDepartment of Chemical Engineering, University of Tennessee, Chattanooga, TN 37403, USA.
Jaison JeevanandamCQM-Centro de Química da Madeira (Madeira Chemistry Center), Universidade da Madeira (University of Madeira), Campus da Penteada (Penteada Campus), 9020-105 Funchal, Portugal.
Ahmed BarhoumNanoStruc Research Group, Chemistry Department, Faculty of Science, Helwan University, Cairo 11795, Egypt.ORCID 0000-0002-4859-5264
Dublin City University · IEUniversidade da Madeira · PTUniversity of Tennessee at Chattanooga · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Janus particles have emerged as a novel and smart material that could improve pharmaceutical formulation, drug delivery, and theranostics. Janus particles have two distinct compartments that differ in functionality, physicochemical properties, and morphological characteristics, among other conventional particles. Recently, Janus particles have attracted considerable attention as effective particulate drug delivery systems as they can accommodate two opposing pharmaceutical agents that can be engineered at the molecular level to achieve better target affinity, lower drug dosage to achieve a therapeutic effect, and controlled drug release with improved pharmacokinetics and pharmacodynamics. This article discusses the development of Janus particles for tailored and improved delivery of pharmaceutical agents for diabetes treatment and antimicrobial applications. It provides an account of advances in the synthesis of Janus particles from various materials using different approaches. It appraises Janus particles as a promising particulate system with the potential to improve conventional delivery systems, providing a better loading capacity and targeting specificity whilst promoting multi-drugs loading and single-dose-drug administration.

Indexed as

drug deliveryformulationJanus particlepharmacodynamicspharmacokinetics

Identifiers

PMID36839746
PMCPMC9967574
OpenAlexW4318480727

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.