Evidence map›Paper›PMID 36839731›Full record

ArticlePharmaceutics2023

Alternative Pharmacokinetic Metrics in Single-Dose Studies to Ensure Bioequivalence of Prolonged-Release Products at Steady State-A Case Study.

Víctor Mangas-Sanjuán, Marta Simón, Esperanza González-Rojano, Dolores Ochoa, Francisco Abad-Santos, Manuel Román, Mercedes Ramos, Carlos Govantes, Alfredo García-Arieta

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Víctor Mangas-SanjuánDepartment of Pharmacy and Pharmaceutical Technology and Parasitology, University of Valencia, 46100 Valencia, Spain.ORCID 0000-0002-3388-5023
Marta SimónLaboratorios Normon, 28760 Madrid, Spain.
Esperanza González-RojanoClinical Pharmacology Department, Hospital Universitario Clínico San Carlos, Instituto de Investigación Sanitaria del Hospital Clínico San Carlos (IdISSC), 28040 Madrid, Spain.
Dolores OchoaClinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IIS-IP), 28006 Madrid, Spain.
Francisco Abad-SantosClinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IIS-IP), 28006 Madrid, Spain.ORCID 0000-0002-6519-8885
Manuel RománClinical Pharmacology Department, Hospital Universitario de La Princesa, Instituto Teófilo Hernando, Instituto de Investigación Sanitaria la Princesa (IIS-IP), 28006 Madrid, Spain.
Mercedes RamosLaboratorios Normon, 28760 Madrid, Spain.
Carlos GovantesLaboratorios Normon, 28760 Madrid, Spain.
Alfredo García-ArietaDivisión de Farmacología y Evaluación Clínica, Departamento de Medicamentos de Uso Humano, Agencia Española de Medicamentos y Productos Sanitarios, 28022 Madrid, Spain.ORCID 0000-0002-9702-6973
Hospital Universitario de La Princesa · ESAgencia Española de Medicamentos y Productos Sanitarios · ESHospital Clínico San Carlos · ESUniversitat de València · ES

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: this article investigates which PK metrics in a single-dose study (concentration at the end of posology interval, C

Indexed as

bioequivalencepAUCprolonged releasesingle dosesteady state

Identifiers

PMID36839731
PMCPMC9963605
OpenAlexW4318054866

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.