Evidence map›Paper›PMID 36839691›Full record

ReviewPharmaceutics2023

Bio-Inspired Drug Delivery Systems: From Synthetic Polypeptide Vesicles to Outer Membrane Vesicles.

Yu Zhang, Yiming Lu, Yixin Xu, Zunkang Zhou, Yichong Li, Wei Ling, Wenliang Song

Abstract readReview
In one paragraph

Review in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed.

  1. Article
  2. Article
  3. A molecular grammar for programmable multiphase protein-RNA vesicles.bioRxiv : the preprint server for biology · 2026
    Article
  4. Review
  5. Review
  6. Article
  7. Review
  8. Article
  9. Article
  10. Application of Cyclodextrin for Cancer Immunotherapy.Molecules (Basel, Switzerland) · 2023
    Review
  11. Article
  12. Article
  13. Review
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yu ZhangSchool of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Yiming LuSchool of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Yixin XuSchool of Pharmacy, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China.
Zunkang ZhouSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Yichong LiSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Wei LingSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.
Wenliang SongSchool of Materials and Chemistry, University of Shanghai for Science and Technology, Shanghai 200093, China.ORCID 0000-0002-8005-5460

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nanomedicine is a broad field that focuses on the development of nanocarriers to deliver specific drugs to targeted sites. A synthetic polypeptide is a kind of biomaterial composed of repeating amino acid units that are linked by peptide bonds. The multiplied amphiphilicity segment of the polypeptide could assemble to form polypeptide vesicles (PVs) under suitable conditions. Different from polypeptide vesicles, outer membrane vesicles (OMVs) are spherical buds of the outer membrane filled with periplasmic content, which commonly originate from Gram-negative bacteria. Owing to their biodegradability and excellent biocompatibility, both PVs and OMVs have been utilized as carriers in delivering drugs. In this review, we discuss the recent drug delivery research based on PVs and OMVs. These related topics are presented: (1) a brief introduction to the production methods for PVs and OMVs; (2) a thorough explanation of PV- and OMV-related applications in drug delivery including the vesicle design and biological assessment; (3) finally, we conclude with a discussion on perspectives and future challenges related to the drug delivery systems of PVs and OMVs.

Indexed as

biological propertiesdrug deliveryouter membrane vesiclespolypeptides vesicles

Identifiers

PMID36839691
PMCPMC9965272

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.