Evidence map›Paper›PMID 36839650›Full record

ArticlePharmaceutics2023

Comparing Salivary Caffeine Kinetics of

Michael Grimm, Adrian Rump, Lisa Meilicke, Maximilian Feldmüller, Rebecca Keßler, Eberhard Scheuch, Mladen Vassilev Tzvetkov, Werner Weitschies

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Does the appearance of theInternational journal of pharmaceutics: X · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Michael GrimmDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0002-1310-7435
Adrian RumpDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-1335-2809
Lisa MeilickeDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.
Maximilian FeldmüllerDepartment of Clinical Pharmacology, Bayer AG Pharmaceuticals, 13353 Berlin, Germany.ORCID 0000-0002-4316-2398
Rebecca KeßlerDepartment of Diagnostic Radiology and Neuroradiology, University Hospital Greifswald, 17475 Greifswald, Germany.ORCID 0000-0002-7773-2328
Eberhard ScheuchDepartment of Clinical Pharmacology, University Hospital Greifswald, 17487 Greifswald, Germany.
Mladen Vassilev TzvetkovDepartment of Clinical Pharmacology, University Hospital Greifswald, 17487 Greifswald, Germany.
Werner WeitschiesDepartment of Biopharmaceutics and Pharmaceutical Technology, University of Greifswald, 17489 Greifswald, Germany.ORCID 0000-0003-3492-7747
Universität Greifswald · DEUniversitätsmedizin Greifswald · DEBayer (Germany) · DE

Funding

German Federal Ministry for Education and Research Grant No. 03IPT612X
6 · The paper itself

Abstract

Gastric water emptying as a critical parameter for oral drug absorption can be investigated by several imaging techniques or by the interpretation of pharmacokinetics of appropriate substances. Recently introduced salivary caffeine kinetics is a valuable tool, but the required caffeine abstinence limits its applicability. To avoid the caffeine abstinence, stable isotope-labeled caffeine might be used, but the representability and transferability of kinetics for evaluation of gastric emptying must be demonstrated. Thus, salivary caffeine pharmacokinetics were compared for naturally occurring

Indexed as

caffeinegastric emptyingmagnetic resonance imaging (MRI)saliva tracersstable isotopesUNGAP

Identifiers

PMID36839650
PMCPMC9963808
OpenAlexW4317425912

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.