Evidence map›Paper›PMID 36839613›Full record

ArticlePathogens (Basel, Switzerland)2023

Tse-Hung Huang, Pei-Wen Hsieh, Tsu-Jung Chen, Hui-Ju Tsai, Ju-Chien Cheng, Hsiang-Ruei Liao, Shun-Li Kuo, Ching-Ping Tseng

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 42% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Tse-Hung HuangDepartment of Traditional Chinese Medicine, Chang Gung Memorial Hospital, Keelung 204, Taiwan.ORCID 0000-0002-5231-9932
Pei-Wen HsiehResearch Center for Chinese Herbal Medicine, Chang Gung University of Science and Technology, Taoyuan 333, Taiwan.ORCID 0000-0002-8882-4711
Tsu-Jung ChenDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Hui-Ju TsaiDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Ju-Chien ChengDepartment of Medical Laboratory Science and Biotechnology, China Medical University, Taichung 404, Taiwan.
Hsiang-Ruei LiaoGraduate Institute of Natural Products, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.
Shun-Li KuoSchool of Traditional Chinese Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-0691-225X
Ching-Ping TsengGraduate Institute of Biomedical Sciences, College of Medicine, Chang Gung University, Taoyuan 333, Taiwan.ORCID 0000-0002-2587-210X
Chang Gung University · TWChang Gung University of Science and Technology · TWChina Medical University · TW

Funding

Chang Gung Medical Foundation CMRPD1K0071-2, CORPD1K0031, CORPG2J0043, and BMRP466China Medical University Hospital CMU108-MF-44National Science and Technology Council 109-2320-B-182-031-MY3 and 111-2321-B-182-001
6 · The paper itself

Abstract

Platelet hyper-reactivity and neutrophil extracellular trap (NET) formation contribute to the development of thromboembolic diseases for patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study investigated the pathophysiological effects of SARS-CoV-2 surface protein components and the viral double-stranded RNA (dsRNA) on platelet aggregation and NET formation. Traditional Chinese medicine (TCM) with anti-viral effects was also delineated. The treatment of human washed platelets with SARS-CoV-2 spike protein S1 or the ectodomain S1 + S2 regions neither caused platelet aggregation nor enhanced agonists-stimulated platelet aggregation. Moreover, NET formation can be induced by polyinosinic-polycytidylic acid (poly(I:C)), a synthetic analog of viral dsRNA, but not by the pseudovirus composed of SARS-CoV-2 spike, envelope, and membrane proteins. To search for TCM with anti-NET activity, the plant

Indexed as

double-stranded RNAneutrophil extracellular trapplatelet aggregationSARS-CoV-2 infectiontraditional Chinese medicine

Identifiers

PMID36839613
PMCPMC9965883
OpenAlexW4321374656

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.