Evidence map›Paper›PMID 36839596›Full record

ReviewPathogens (Basel, Switzerland)2023

T Cell Response to SARS-CoV-2 Coinfection and Comorbidities.

Liqing Wang, Hao-Yun Peng, Aspen Pham, Eber Villazana, Darby J Ballard, Jugal Kishore Das, Anil Kumar, Xiaofang Xiong, Jianxun Song

Abstract readReview
In one paragraph

Review in Pathogens (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Role of T Cells in Microbial Pathogenesis.Pathogens (Basel, Switzerland) · 2023
    Article
  7. T Cells in Pathogenic Infections.Pathogens (Basel, Switzerland) · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liqing WangDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Hao-Yun PengDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0001-5151-590X
Aspen PhamDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Eber VillazanaDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Darby J BallardDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Jugal Kishore DasDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Anil KumarDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-7611-5918
Xiaofang XiongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.
Jianxun SongDepartment of Microbial Pathogenesis and Immunology, Texas A&M University Health Science Center, Bryan, TX 77807, USA.ORCID 0000-0002-9734-6176

Funding

Nucleus Accumbens-Associated Protein-1 in Melanoma ImmunotherapyR01CA221867 · NCI · UNIVERSITY OF KENTUCKY · PI SONG, JIANXUN JIM, YANG, JIN-MING · 2018 to 2023
$2.8M
Stem cell-derived regulatory T cells for therapeutic use in arthritisR01AI121180 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2016 to 2020
$1.9M
Combating melanoma with an attenuated bacterial therapeuticR01CA273002 · NCI · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI Jianxun Jim Song · 2023 to 2026
$1.8M
Combating chronic neuroinflammatory disorders by targeting NAC1R21AI167793 · NIAID · TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR · PI SONG, JIANXUN JIM · 2022 to 2023
$413k
NCI NIH HHS R01 CA221867NIAID NIH HHS R01 AI121180NIAID NIH HHS R21 AI167793NIH HHS R01CA221867,R01AI121180 and R21AI167793
6 · The paper itself

Abstract

For the past three years, COVID-19 has become an increasing global health issue. Adaptive immune cells, especially T cells, have been extensively investigated in regard to SARS-CoV-2 infection. However, human health and T cell responses are also impacted by many other pathogens and chronic diseases. We have summarized T cell performance during SARS-CoV-2 coinfection with other viruses, bacteria, and parasites. Furthermore, we distinguished if those altered T cell statuses under coinfection would affect their clinical outcomes, such as symptom severity and hospitalization demand. T cell alteration in diabetes, asthma, and hypertension patients with SARS-CoV-2 infection was also investigated in our study. We have summarized whether changes in T cell response influence the clinical outcome during comorbidities.

Indexed as

coinfectioncomorbiditiesSARS-CoV-2T cells

Identifiers

PMID36839596
PMCPMC9965203

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.