Evidence map›Paper›PMID 36839414›Full record

ArticleNutrients2023

The Ketogenic Diet in Children with Epilepsy: A Focus on Parental Stress and Family Compliance.

Francesca Felicia Operto, Angelo Labate, Salvatore Aiello, Cristina Perillo, Valeria de Simone, Rosetta Rinaldi, Giangennaro Coppola, Grazia Maria Giovanna Pastorino

Abstract read
In one paragraph

Article in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Article
  2. Can Artificial Intelligence Chatbots Plan Therapeutic Ketogenic Diets for Children With Epilepsy?Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2026
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  3. Article
  4. Review
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  7. Psychometric properties of the Parenting Stress Index-Short Form in a Peruvian sample.Psicologia, reflexao e critica : revista semestral do Departamento de Psicologia da UFRGS · 2024
    Article
  8. Article
  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Francesca Felicia OpertoChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-2444-8761
Angelo LabateNeurophysiopatology and Movement Disorders Clinic, University of Messina, 98122 Messina, Italy.
Salvatore AielloChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-9764-3058
Cristina PerilloChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.
Valeria de SimoneChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.
Rosetta RinaldiChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.
Giangennaro CoppolaChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0002-9574-0081
Grazia Maria Giovanna PastorinoChild and Adolescent Neuropsychiatry Unit, Department of Medicine, Surgery, and Odontoiatry, University of Salerno, 84084 Salerno, Italy.ORCID 0000-0003-0404-5495

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

(1) Background: The aim of our study was to evaluate parental stress after 6 and 12 months of a ketogenic diet, considering demographic and clinical variables (epilepsy type, epilepsy duration, seizure number, antiseizure medications, comorbidities, efficacy, and adverse events). (2) Methods: We consecutively enrolled 36 children aged between 3 and 10 years who had been diagnosed with various types of drug-resistant epilepsy and who were in therapy with a ketogenic diet for better seizure control. A standardized neuropsychological questionnaire (Parenting Stress Index-PSI) was administered to the parents evaluating parental stress at baseline (T0), after 6 (T1) months, and after 12 months (T2). (3) Results: After 6 and 12 months of dietary treatment, Parental Distress and Total Stress mean scores were statistically significantly increased. Post hoc analysis showed no significant changes in the scores between T0 and T1, although there was a significant increase between T1 and T2. We did not find statistically significant relationships between parental stress and the other variables considered. (4) Conclusions: The ketogenic diet can be challenging for parents and can affect the perception of parental stress, especially in the long term. Parents may feel inadequate in their role; therefore, they should be helped and encouraged through additional supports in order to maximize the adherence to diet therapy.

Indexed as

Diet, KetogenicEpilepsyChildChild, PreschoolHumansParentsSeizuresTreatment Outcomechildrenepilepsyketogenic dietparental stress

Identifiers

PMID36839414
PMCPMC9958546

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.