Evidence map›Paper›PMID 36839259›Full record

SynthesisNutrients2023

Two Faces of Catechol-O-Methyltransferase Inhibitor on One-Carbon Metabolism in Parkinson's Disease: A Meta-Analysis.

Jin Hee Kim, Shaoyue Jin, Hyeyoon Eo, Myung Sook Oh, Yunsook Lim

Open access · goldAbstract readMeta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Article
  3. Parkinson's disease and vitamins: a focus on vitamin B12.Journal of neural transmission (Vienna, Austria : 1996) · 2024
    Review
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Jin Hee KimDepartment of Biomedical and Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea.
Shaoyue JinSchool of Medicine, Ningbo University, Ningbo 315211, China.
Hyeyoon EoDepartment of Biomedical and Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-1532-613X
Myung Sook OhDepartment of Biomedical and Pharmaceutical Science, Kyung Hee University, Seoul 02447, Republic of Korea.
Yunsook LimDepartment of Food and Nutrition, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.ORCID 0000-0002-3408-8595
Kyung Hee University · KRNingbo University · CN

Funding

National Research Foundation of Korea 2022M3A9B6017813National Research Foundation of Korea NRF-2017R1A5A2014768
6 · The paper itself

Abstract

Levodopa (L-dopa) and catechol-O-methyltransferase (COMT) inhibition are widely used therapeutics in Parkinson's disease (PD). Despite their therapeutic effects, it was raised that nutrients involved in one-carbon metabolism can be deteriorated by PD therapies. The aim of this meta-analysis was to investigate the impact of L-dopa and COMT inhibitors on levels of homocysteine (Hcy), vitamin B

Indexed as

Catechol O-Methyltransferase InhibitorsParkinson DiseaseCarbonFolic AcidHomocysteineHumansLevodopaVitamin B 12VitaminsCarbonCatechol O-Methyltransferase InhibitorsFolic AcidHomocysteineLevodopaVitamin B 12Vitaminsfolatehomocysteinelevodopameta-analysisone-carbon metabolismParkinson’s diseasevitamin B

Identifiers

PMID36839259
PMCPMC9964466
OpenAlexW4320497362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.