Evidence map›Paper›PMID 36839248›Full record

Trial reportNutrients2023

Caloric Restriction (CR) Plus High-Nitrate Beetroot Juice Does Not Amplify CR-Induced Metabolic Adaptation and Improves Vascular and Cognitive Functions in Overweight Adults: A 14-Day Pilot Randomised Trial.

Mushari Alharbi, Martina Chiurazzi, Gilda Nasti, Espedita Muscariello, Teresa Mastantuono, Christina Koechl, Blossom Cm Stephan, Oliver M Shannon, Antonio Colantuoni, Mario Siervo

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nutrients, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06151015 (Testing the Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function in Older Adults Living with Overweight or Obesity), which is not on this map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06151015 narecruitingnot on this mapstarted 2024, after this paper: background citation

Testing the Combined Effect of Dietary Nitrate and Caloric Restriction on Cognitive and Vascular Function in Older Adults Living with Overweight or Obesity: a 28-Day Pilot Randomised Trial

TypeinterventionalSponsorMoira TaylorRan2024 to 2025Enrolled20ConditionsHealthy, Older Adults, Overweight and ObesityArmsNitrate-rich beetroot juice plus calorie-restricted diet, Nitrate-rich beetroot juice plus weight-maintenance diet
3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 4 countries.

Mushari AlharbiSchool of Life Sciences, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.ORCID 0000-0003-4273-9674
Martina ChiurazziDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
Gilda NastiDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini, 5, 80131 Naples, Italy.ORCID 0000-0001-6436-0281
Espedita MuscarielloDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
Teresa MastantuonoDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
Christina KoechlHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Blossom Cm StephanInstitute of Mental Health, The University of Nottingham Medical School, Nottingham NG7 2UH, UK.
Oliver M ShannonHuman Nutrition Research Centre, Population Health Sciences Institute, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Antonio ColantuoniDepartment of Clinical Medicine and Surgery, Federico II University of Naples, Via S. Pansini, 5, 80131 Naples, Italy.
Mario SiervoSchool of Life Sciences, The University of Nottingham Medical School, Queen's Medical Centre, Nottingham NG7 2UH, UK.
University of Naples Federico II · ITUniversity of Nottingham · GBNewcastle University · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Caloric restriction (CR) and dietary nitrate supplementation are nutritional interventions with pleiotropic physiological functions. This pilot study investigates the combined effects of CR and nitrate-rich beetroot juice (BRJ) on metabolic, vascular, and cognitive functions in overweight and obese middle-aged and older adults. This was a two-arm, parallel randomized clinical trial including 29 participants allocated to CR + BRJ (

Indexed as

Beta vulgarisNitratesAgedAntioxidantsBlood PressureCaloric RestrictionCognitionDietary SupplementsDouble-Blind MethodFruit and Vegetable JuicesHumansMiddle AgedOverweightPilot ProjectsAntioxidantsNitratescaloric restrictioncognitive functiondietary nitrateendothelial functionnitric oxideobesity

Identifiers

PMID36839248
PMCPMC9962072
OpenAlexW4319969370

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.