Evidence map›Paper›PMID 36838963›Full record

ArticleMolecules (Basel, Switzerland)2023

A Natural Glucan from Black Bean Inhibits Cancer Cell Proliferation via PI3K-Akt and MAPK Pathway.

Peng Li, Yihua Hu, Lingmin Zhan, Jiaqi He, Jingwu Lu, Chunyan Gao, Weijun Du, Aiqin Yue, Jinzhong Zhao, Wuxia Zhang

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.4field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 6 citations in OpenAlex.

  1. In vitro approaches to assess respiratory toxicity from volatile organic compounds: an in-depth review.Toxicological sciences : an official journal of the Society of Toxicology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Peng LiDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Yihua HuDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Lingmin ZhanDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Jiaqi HeDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Jingwu LuDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Chunyan GaoDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Weijun DuCollege of Agriculture, Shanxi Agricultural University, Taigu 030801, China.
Aiqin YueCollege of Agriculture, Shanxi Agricultural University, Taigu 030801, China.
Jinzhong ZhaoDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Wuxia ZhangDepartment of Basic Sciences, Shanxi Agricultural University, Taigu 030801, China.
Shanxi Agricultural University · CN

Funding

National Natural Science Foundation of China 82274363;31800678the Distinguished and Excellent Young Scholars Cultivation Project of Shanxi Agricultural University 2022YQPYGC09
6 · The paper itself

Abstract

A natural α-1,6-glucan named BBWPW was identified from black beans. Cell viability assay showed that BBWPW inhibited the proliferation of different cancer cells, especially HeLa cells. Flow cytometry analysis indicated that BBWPW suppressed the HeLa cell cycle in the G2/M phase. Consistently, RT-PCR experiments displayed that BBWPW significantly impacts the expression of four marker genes related to the G2/M phase, including

Indexed as

GlucansNeoplasmsProto-Oncogene Proteins c-aktApoptosisCell Line, TumorCell ProliferationHeLa CellsHumansPhaseolusPhosphatidylinositol 3-KinasesPhytochemicalsGlucansPhosphatidylinositol 3-KinasesPhytochemicalsProto-Oncogene Proteins c-aktanti-cancer activityblack beancell cycle arrestMAPKPI3K/Aktpolysaccharide

Identifiers

PMID36838963
PMCPMC9961350
OpenAlexW4321375725

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.