Evidence map›Paper›PMID 36838913›Full record

ArticleMolecules (Basel, Switzerland)2023

Novel 2-Thiouracil-5-Sulfonamide Derivatives: Design, Synthesis, Molecular Docking, and Biological Evaluation as Antioxidants with 15-LOX Inhibition.

Naglaa M Ahmed, Ahmed H Lotfallah, Mohamed S Gaballah, Samir M Awad, Moustafa K Soltan

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.8field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 2 countries.

Naglaa M AhmedPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.ORCID 0000-0001-5864-2370
Ahmed H LotfallahDepartment of Pharmaceutical Chemistry, Faculty of Pharmacy, Sinai University, El-Arish 16020, Egypt.
Mohamed S GaballahBiochemistry Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.ORCID 0000-0001-7484-6015
Samir M AwadPharmaceutical Organic Chemistry Department, Faculty of Pharmacy, Helwan University, Ein Helwan, Cairo 11795, Egypt.
Moustafa K SoltanMinistry of Health, Oman College of Health Sciences, Muscat 132, Oman.ORCID 0000-0001-6021-907X
Helwan University · EGSinai University · EGZagazig University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

New antioxidant agents are urgently required to combat oxidative stress, which is linked to the emergence of serious diseases. In an effort to discover potent antioxidant agents, a novel series of 2-thiouracil-5-sulfonamides (

Indexed as

AntioxidantsArachidonate 15-LipoxygenaseAscorbic AcidHumansHydrogen PeroxideMolecular Docking SimulationMolecular StructureStructure-Activity RelationshipSulfonamidesAntioxidantsArachidonate 15-LipoxygenaseAscorbic AcidHydrogen PeroxideSulfonamides15-LOXantioxidantDPPHmolecular dockingsulfonamides

Identifiers

PMID36838913
PMCPMC9963659
OpenAlexW4321377013

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.