Evidence map›Paper›PMID 36838906›Full record

ArticleMolecules (Basel, Switzerland)2023

Synthetic Cinnamides and Cinnamates: Antimicrobial Activity, Mechanism of Action, and In Silico Study.

Mayara Castro de Morais, Edeltrudes de Oliveira Lima, Yunierkis Perez-Castillo, Damião Pergentino de Sousa

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

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  5. FabH (β-Ketoacyl-ACP Synthase III) -- Promising Novel Antibacterial Target and Its Inhibitors.Medicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026
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  9. Metabolomics navigates natural variation in pathogen-induced secondary metabolism across soybean cultivar populations.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  13. Review
  14. Review
  15. Article
  16. Article
  17. Antifungal activities andJournal of advanced pharmaceutical technology & research
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 2 institutions in 2 countries.

Mayara Castro de MoraisDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0001-5967-9554
Edeltrudes de Oliveira LimaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.
Yunierkis Perez-CastilloBio-Cheminformatics Research Group and Area de Ciencias Aplicadas, Facultad de Ingeniería y Ciencias Aplicadas, Universidad de Las Americas, Quito 170503, Ecuador.ORCID 0000-0002-3710-0035
Damião Pergentino de SousaDepartment of Pharmaceutical Sciences, Federal University of Paraíba, João Pessoa 58051-900, PB, Brazil.ORCID 0000-0002-7180-4896
Universidade Federal da Paraíba · BRUniversidad de Las Américas · EC

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The severity of infectious diseases associated with the resistance of microorganisms to drugs highlights the importance of investigating bioactive compounds with antimicrobial potential. Therefore, nineteen synthetic cinnamides and cinnamates having a cinnamoyl nucleus were prepared and submitted for the evaluation of antimicrobial activity against pathogenic fungi and bacteria in this study. To determine the minimum inhibitory concentration (MIC) of the compounds, possible mechanisms of antifungal action, and synergistic effects, microdilution testing in broth was used. The structures of the synthesized products were characterized with FTIR spectroscopy,

Indexed as

Antifungal AgentsAnti-Infective AgentsAnti-Bacterial AgentsCandida albicansCinnamatesMicrobial Sensitivity TestsMolecular Docking SimulationStaphylococcus aureusTriiodobenzoic AcidsAnti-Bacterial AgentsAntifungal AgentsAnti-Infective AgentsCinnamatescompound 18Triiodobenzoic AcidsamidesantimicrobialCandidacinnamic acidestersmechanism of actionmedicinal plantmolecular dockingnatural productS. aureus

Identifiers

PMID36838906
PMCPMC9967511
OpenAlexW4321232615

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.